Diffusive function of lung is one of the important parameters in
respiration research. Gas exchange across the lung is altered in
different pathological conditions such as in pulmonary fibrosis
and in other obstructive and restrictive diseases. Exposure to
radiation also causes altered lung function. Scientists have been
using mice and transgenic mice for establishing the effects
some respiration related gene expression on respiratory function
in mice. We have developed a technique to measure lung function
in mice by carbon monoxide uptake method. Although the carbon
monoxide uptake in mammals is dependent on the rate of alveolar
ventilation and the diffusive function of lung epithelium, the
measurement of carbon monoxide uptake can be used as an important
parameter in screening the impairment of lung function caused by
radiation, environmental polutants and toxic and irritable
inhalant. If you are interested in measuring diffusive function
of lung in laboratory animals, please provide your address and I
will send you all necessary information.
PKG
Internet: 75144.2413 at compuserve.com
