Does anyone have a few references to the mechanism by which
chloramphenicol (and other nitroaromatic antibiotics) are rendered
ineffective. I've heard of low membrane permeability, active transport
of Chl out of the cell and acetylation, but I don't have any of the
references for these. Also, are gram-positive organisms likely to be
more sensitive to chloramphenicol/nitroaromatic compounds?
Any help would be much appreciated.
Mark Fuller, Ph. D.
Environmental Research Division ER/203-J070
Argonne National Laboratory
Argonne, IL 60439-4843
phone: (708) 252-1795
FAX: (708) 252-8895
email: mark_fuller at qmgate.anl.gov