Two hypotheses seems to emerge to explain metal carcinogenicity:
induction of oxidative damage and interaction with DNA repair. However,
can metals cause promutagenic damage such as DNA strand breaks !!! I
am looking for any relevant reference underlying the mechanism.
Thanks for any help or reference.
Michel Assad
Canada
E-mail: assad at justine.umontreal.ca
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* Michel Assad
* Paediatric Research Center
* Ste-Justine Hospital
* 3175, Cote Ste-Catherine
* Montreal (Quebec) H3T 1C5
* CANADA
*
* PHONE (office): (514) 345-4796
* (home): (514) 271-4633
* FAX: (514) 345-4723
* E-MAIL: assad at justine.umontreal.ca
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