BIONET announcements/conferences of interest to toxicologists

Chuck Miller rellim at MAILHOST.TCS.TULANE.EDU
Thu Jul 18 15:46:33 EST 1996


From: Dr Tim Kedwards
ZENECA Agrochemicals
Ecological Risk Assessment Section
Jealott's Hill Research Station
Bracknell, UK
RG42 6ET

Tel:            +44 (0) 1344 414107
Fax:            +44 (0) 1344 414124
Email:          Tim.T.J.Kedwards at gbjha.zeneca.com
Disclaimer:-    'The opinions expressed herein are my personal opinions
                and do not necessarily represent those of my employer'

Saturday, 16 November 1996, 8:30 - 5:30, Washington Hilton and Towers
Presented in conjunction with the SETAC 17th Annual Meeting,
Washington, D.C.

Frameworks for ecological risk assessment often culminate in the
evaluation of effects under simulated or actual environmental conditions.
A fundamental objective of such semi-field and field studies is to investigate
effects at the community and ecosystem level.  To this end, data are collected 
ona large number of  ecological variables, including manipulative experiments 
(artificial streams, mesocosms, terrestrial field trials), environmental
monitoring (before/after,upstream/downstream), and ecological surveys
(plants, bird census).

Data from these studies are usually evaluated by using univariate
statistics (e.g. analysis of variance, concentration-response regression).  
These havelimitations because it is only possible to look at a limited
number of variables within the ecosystem at any one time, limiting effects
determination to the
population level, whereas the objective is normally to understand effects at 
higher levels of organization.

The advent of greater computing power and recent developments of new
multivariate statistical tools has made available a variety of techniques (e.g.
CANOCO, RIFFLE, PRIMER) with the potential to overcome some of these previous
limitations.  Consequently, there is growing interest among ecotoxicologists in
applying such techniques to field studies in order to be able to generate true
community and ecosystem endpoints.  This workshop will provide an excellent
opportunity for interested individuals to meet and exchange views on these 
approaches and allow developers of the statistical approaches to discuss
the development and application of the techniques.

The objective of this workshop is to provide information on and  generate discus
sion of multivariate statistical techniques in ecotoxicological field
studies, focusi
ng on the application of techniques for generating community and ecosystem
level statistics, rather than mathematical derivation.

Attendance will be limited to 100 people to maximize information
exchange. Registration is first-come, first served.  The registration fee is
$255, and forms can be obtained from the SETAC Office.

Workshop proceedings will be provided to all registrants at no
additional cost, and will be available for purchase by others after the workshop
                         SETAC Office
                    1010 North 12th Avenue
                   Pensacola, Florida  32501
     T 904-469-1500    F 904-469-9778    E setac at setac.org

The Antibody Resource Page has recently been updated.  This website is
the only one on the web devoted to collecting links and useful
information about antibodies.  The webpage contains educational links
about antibodies (some with incredible graphics), links to on-line
journals that cover antibody-related topics, an essay on the study of
antibody molecular recognition, links to on-line antibody sequencing
and hybridoma databases, and a miscellaneous section.

I also have a large section designed to help those looking for an
antibody:  This latter section contains more than 60 links to on-line
companies that sell antibodies, many which have searchable catalogues.
This section also contains useful tips on how to find antibodies using
the internet or otherwise.

I am always looking for new links to add to my page, so if you know of
any, please let me know via email.  Or just email me to let me know
what you think of the page!  The URL for the Antibody Resource Page
is: http://www-chem.ucsd.edu/Faculty/goodman/antibody.html/abpage.html
Kevin Shreder, Ph.D.
kshreder at ucsd.edu

From: horaitis at ariel.ucs.unimelb.edu.au (Rania Horaitis)
We are trying to establish a database of mutations,and we thought some of
you may be interested in the formation of an alliance of database curators
and a mutation database association.

I am forwarding you information about a web site, if anyone is interested
please fill out the questionnaire (contained in the web site) and email it
back to me. (Some of you may already have received this, if so , you do not
need to
fill it out again, it means that you are on another mailing list).

Could you also indicate how you received information about this initaitive;
ie: bionews,mutation,personal email etc...?

A mutation database website has been set up to facilitate communication
between those interested in locus specific mutation databases and their
integration into a system which allows access via computers to up to date
lists of mutations in genes.

We have set up this website in the interest of effective communication  to
distribute relevant material regarding the initiative, as well as promote
discussion about plans.

This is a collaboration between R.Cotton, C.Scriver and V.McKusick.
The address: http://ariel.ucs.unimelb.edu.au:80/~cotton/mut_database.htm
Rania Horaitis
Mutation Research Centre
St.Vincents Hospital,
41 Victoria Pde,
Fitzroy, Melb.
VIC 3062
pH: 61-3-9288-2982
Fax: 61-3-9288-2989

From: "Heinz Rupp, PhD" <rupp at Papin.HRZ.Uni-Marburg.DE>
Subject: International Society for Molecular Nutrition and Therapy

Objectives of the ISMNT (Cardiovascular Drugs and Therapy
1996;10(suppl. 1): Preface).

     Nutrients and drugs are recognized as two main ways of
maintaining health and well-being and both of them rely on a
molecular basis. However, no scientific society is focussed
on molecular mechanisms of the action of nutrients and drugs
and their mutual interactions. Most of chronic diseases are
related to cellular alterations which can, in part, be
influenced by nutrients. Similarly, the efficiency of
therapeutic drugs can be modulated by nutrients.

     We thought it timely to create a new scientific society
which will focus on the mechanisms of specific effects of
nutrients and drugs in chronic diseases, their possible
interactions as well as the mechanism of their protective or
therapeutic action. Besides highlightning of these
mechanisms, the objective of the society is to contribute to
the elaboration of guidelines for optimization of the dietary
prevention of diseases and the dietary optimization of each
therapeutic drug approach.

     We believe that such a goal cannot be efficiently
achieved in the existing scientific societies which represent
mainly traditional disciplines. Thus, there is a need to
bring together nutritionists, pharmacologists, pathologists,
toxicologists, physiologists, biochemists, clinicians -all
involved in the common goal of explanation of the molecular
mechanisms underlying specific (beneficial or adverse)
effects of nutrients and drugs in health.

     This approach has become feasible because our
understanding of molecular events has greatly improved in the
last decade. Furthermore, numerous methodological
improvements (e.g. stable isotopes, human cell culture and
molecular genetics) are offering growing opportunities for
investigations on human tissues.

     Scientists, medical doctors and teachers of
universities, hospitals, national and international research
institutions, food and pharmaceutical companies, and any
person showing interest in this scope will be welcome in the

                   MOLECULAR NUTRITION
                        AND THERAPY
     The First Meeting of the ISMNT was held in Stuttgart
June 29, 1995. The meeting focused on nutritional influences
on sympathetic nervous system activity in man and
experimental animals. Consequences of a prolonged sympathetic
activity were described for the integrity of the
cardiovascular system. In accordance with the aims of the
ISMNT, drug interventions were discussed which provide a
novel approach for patients suffering from an excess
sympathetic outflow of the brain. A second generation of
(antihypertensive) drugs were presented which reduce
sympathetic outflow of the brain but have greatly reduced
side effects. The proceedings of the meeting are published as
supplement to Cardiovascular Drugs and Therapy 1996;10
(suppl. 1): 215-289 The Excess Catecholamine Syndrome. From
Cause to Therapy

From: bhenry at biotrin.ie (Barney Henry)
Subject: Conference - GSH and related Proteins in Human Disease (Oct/Nov '96)
View this announcement at http://www.biotrin.ie/biotrin/gstconf.htm
                International Conference
           Glutathione and Glutathione-Linked
        Enzymes in Human Cancer and Other Diseases
     ( Biology, Diagnosis, Therapy and Prevention )

              October 31 - November 3, 1996
           Hilton Head, South Carolina, U.S.A.

*Scope and Aims*
Recent research advances on the role of glutathione, glutathione
S-transferases and other GSH linked proteins in normal cellular functions
and pathologic processes are providing novel concepts for improved
diagnosis, therapy, risk assessment and prevention of human cancer and other

A number of clinical trials have been instituted based on these advances.
GSH and its related enzymes are also being actively investigated as targets
in the development of novel therapeutic agents and strategies in the therapy
of cancer and other diseases, and in the monitoring of normal tissue injury.

This conference will focus on recent reserach findings and developments,
particularly in the field of biochemistry, cell and molecular biology, and
genetics of glutathione, glutathione S-transferases and other glutathione
linked proteins, as they relate to the diagnosis, therapy and prevention of
human disease. The scientific sessions will cover a variety of topics,
including cell and molecular biology, gene regulation, drug and radiation
resistance, toxicology and drug metabolism, pathology, drug development,
epidemiology and prevention, and clinical trials. The conference will
summarize current knowledge in this rapidly evolving field and discuss areas
and challenges for future focus in both basic and translational research.

For Further information & Registration details, Contact :-
     Patricia Richter (Conference Secretary)
     Department of Experimental Pediatrics
     UT MD Anderson Cancer Center
     Houston, TX 77030, USA
     Tel: (713) 792-3495; Fax: (713) 794-5514
     E-Mail: Ali-Osman at utmdacc.mda.tmc.edu

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