Vincristine Encephalopathy

user at rbarcan.softnet.co.uk user at rbarcan.softnet.co.uk
Thu Jan 30 04:04:01 EST 1997

I need urgent information as to the association between central neuropathy and 
the administration of Vincristine given by the intravenous route ( not 
intrathecally). There are several reports in the the literature of Vincristine 
encephalopathy in the 1970s but does anyone have more recent examples? In my 
case VCR was given on days 1 and 4 for a Wilms Tumour. Radiotherapy to the 
brain was also given as it was thought there was a metastasis. The outcome was 
irreversible and extensive brain damage.

I would be grateful for all comments
Richard Barcan


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