pH of IV injection

Mike Holland jmhollan at sprynet.com
Mon May 5 09:21:02 EST 1997

Tom Wallace wrote:
> What is the acceptable upper limit for the pH of intravenous drug =
> formulations? Can rats tolerate an intravenous injection once daily for =
> seven days with a drug formulated at pH 9-10?

Yes, rats can tolerate these pH's for prolonged periods, but there is
more to this question than pH, volumes, osmolality, molarity, ions...
You need to supply much more information to obtain worthwhile answers.

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