PAHs and bay/fjord region

Chuck Miller rellim at MAILHOST.TCS.TULANE.EDU
Wed Sep 3 10:24:56 EST 1997

Annelise  <lsmi at chimie.u-strasbg.fr> wrote
>I wonder what is the bay region and apparently its opposite side, the
>fjord one in PAHs (Polycyclic Aromatic Hydrocarbones)? Is there any
>bibliography available on the subject? It has a special interest for
>toxicologists who are working on cancerogenesis and metabolism of such
>compounds (PAHs) by P 450. Thanks in advance, Annelise

See an old, but good book for a good explanation of PAH metabolism.

B. Singer and D. Grunberger, 1983, Molecular Biology of Mutagens and
Carcinogens, Plenum Press, New York.

Here are a few more recent references to get you going.

Ralston SL, Stereoselective activation of dibenzo[a,l]pyrene and its
trans-11,12 -dihydrodiol to fjord region 11,12-diol 13,14-epoxides in a
human mammary carcinoma MCF-7 cell-mediated V79 cell mutation assay. Chem
Res Toxicol 10(6), 687-693 (1997)

Phillips DH, Relationship between mutagenicity and DNA adduct formation in
mammalian cells for fjord- and bay-region diol-epoxides of polycyclic
aromatic hydrocarbons. Chem Biol Interact 80(2), 177-186 (1991)

 Chary P,  In vivo and in vitro replication consequences of stereoisomeric
benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide adducts on adenine N6 at the
second position of N-ras codon 61. J Biol Chem 270(10), 4990-5000 (1995)

Dr. Charles A. Miller, rellim at mailhost.tcs.tulane.edu
Bionet.toxicology news group:
Dept. Environmental Health Sciences, SL29
Center for Bioenvironmental Research
Tulane Univ. School of Public Health and Tropical Medicine
1430 Tulane Ave.
New Orleans, LA 70112

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