IUBio

LD50 determination

DUFRASNE FRANCOIS dufrasne at resulb.ulb.ac.be
Tue Sep 9 11:21:16 EST 1997


The answer did not give me satisfaction: I need an OFFICIAL PROTOCOL.

My idee is: devide the group of 100 rats in smaller groups and inject 
growing doses of the toxic substance to each group. I think we can 
obtain a sigmoïd-shape curve and, after a probit transformation, obtain 
the LD50 by a simple graphic extrapolation.
I don't know whether the answer is satisfactory.




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