There is an enoumous literature base on the application of dose-response
data to the understanding of toxicologic mechanism, the extrapolation of
toxicologic risk across exposure paradigms and species, and the
management
of sources of toxicologic risk. Good references include:
Jarabek, A.M. (1995). "The application of dosimetry models to identify
key
processes and parameters for default dose-response assessment
approaches."
Toxicol. Lett. 79:171-184.
"Science and Judgement in Risk Assessment" by the Committee on Risk
Assessment of Hazardous Air Pollutants of the US National Research
Council
[ISBN 0-309-04894-X].
There are many, many more...
Sonia Sanchez-Galan wrote:
>> I would like to know opinions about the relevance of dose-response
> experiments in toxicology. What information do they provide? What are they
> useful to?
>> *******************************************
> Sonia Sánchez Galán
> Departamento de Biología Funcional
> Area de Genética
> Facultad de Medicina
> C/Julian Clavería, s/n
> 33006 OVIEDO
> Tel.: (98) 5104194
> FAX: (98) 5103534
> e-mail: sonia at sauron.quimica.uniovi.es> *******************************************
--
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Greg Blumenthal (blument1 at niehs.nih.gov)
TEL: 919-541-7791, FAX: 919-541-1479
MD E1-05, NIEHS, P.O.Box 12233, RTP, NC 27709-2233 USA
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