Eradication of cholera?

Lars Andrup andrup at internet.dk
Thu Jan 29 03:15:11 EST 1998

Dear PSB2

This is a very complex subject... Is it the eradication of the bacterium,
Vibrio cholerae, or the disease? 

If its the last, you have to consider the possibility of horizontal DNA
transfer enabeling other microorganisms to cause similar diseases.

There has been, at least one, example that a E. coli was causing the
disease cholera... and it turned out that this coli-strain had acquired the
toxin(s) from the Vibrio and that the genes now reside on a plasmid in coli
(in Vibrio cholerae the toxins are chromosomally encoded). 

In addition, in contrast to smallpox, the Vibrio cholera is not restricted
to humans and can survive and multiply in the environment.

Good luck



*********** ooo O ooo ***********
Lars Andrup, senior researcher
National Institute of Occupational Health
Lersø Parkallé 105, DK-2100 Copenhagen, Denmark
phone:+45 3916-5223 fax: +45 3916-5201
*********** ooo O ooo ***********

psb2 <psb2 at ukc.ac.uk> wrote in article <34CE4FF2.7E7 at ukc.ac.uk>...
> I am carrying out a project which intends to review the eradication of
> diseases. Using the case of smallpox being the first disease
> successfully eradicated by man, I have chosen an example of Cholera to
> investigate the potentiality of its eradication. I am writing to you in
> the hope that you will be able to help me in finding information on this
> topic. 
> 	Thanks in advance.

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