Julia Laylander (jlayland at XMISSION.COM) asked "Is acetylcholinesterase a
Mg-dependent enzyme?"
Julia, as you may know, there are several enzymes with acetylcholinesterase
activity. A quick (and free) search of Medline
(http://www.ncbi.nlm.nih.gov/PubMed/) using keywords acetylcholinesterase
AND magnesium gave these (and many more) references. Happy hunting.
Rodriguez-Ithurralde D, et al. [See Related Articles]
Glycine effects on glutamate-receptor elicited acetylcholinesterase
release from slices and synaptosomes of the
spinal ventral horn.
J Neurol Sci. 1996 Aug; 139 Suppl: 76-82.
PMID: 8899663; UI: 97055376.
Nery da Matta A, et al. [See Related Articles]
Effect of Mg(2+)-ATP on acetylcholinesterase of Electrophorus
electricus (L.).
Z Naturforsch [C]. 1996 Jan; 51(1-2): 65-69.
PMID: 8721214; UI: 96342218.
Johnson G, et al. [See Related Articles]
Acetylcholinesterase of human intestinal tissue affected by
Hirschsprung's disease: effect of magnesium
chloride on isoforms.
Clin Chim Acta. 1995 Dec 29; 243(2): 115-128.
PMID: 8747488; UI: 96340743.
Rodriguez-Ithurralde D, et al. [See Related Articles]
Glutamate-receptor elicited acetylcholinesterase release in mouse
spinal cord slice: a model of early excitotoxic
injury.
J Neurol Sci. 1995 May; 129 Suppl: 104-106.
PMID: 7595597; UI: 96059159.
Inestrosa NC, et al. [See Related Articles]
Sensitivity of acetylcholinesterase molecular forms to inhibition by
high MgCl2 concentration.
Biochim Biophys Acta. 1994 Oct 19; 1208(2): 286-293.
PMID: 7947960; UI: 95035029.
Szabolcs M, et al. [See Related Articles]
Enzymatic properties, metal composition and SH-group reactivity of
the light and heavy sarcoplasmic
reticulum vesicles.
Acta Physiol Hung. 1994; 82(2): 153-162.
PMID: 7887175; UI: 95193533.
Molnar J, et al. [See Related Articles]
Effects of tricyclic compounds on membrane binding of bivalent
cations, activities of acetylcholinesterase and
some tissue proteases.
In Vivo. 1993 Sep; 7(5): 431-434.
PMID: 8110987; UI: 94154192.
Giniatullin RA, et al. [See Related Articles]
A correlation between quantal content and decay time of endplate
currents in frog muscles with intact
cholinesterase.
J Physiol (Lond). 1993 Jul; 466: 95-103.
PMID: 8410718; UI: 94015983.
Farms WB, et al. [See Related Articles]
Effect of copper-deficient diet on metabolism in rat auditory
structures.
Hear Res. 1993 May; 67(1-2): 45-50.
PMID: 8101836; UI: 93339987.
Besser R, et al. [See Related Articles]
Impaired neuromuscular transmission during partial inhibition of
acetylcholinesterase: the role of
stimulus-induced antidromic backfiring in the generation of the
decrement-increment phenomenon.
Muscle Nerve. 1992 Oct; 15(10): 1072-1080.
PMID: 1328879; UI: 93024671.
Giniatullin RA, et al. [See Related Articles]
[Non-quantal secretion of a mediator as factor determining
consequences of acetylcholinesterase inhibition].
Biull Eksp Biol Med. 1992 Jul; 114(7): 6-7. Russian.
PMID: 1421312; UI: 93043229.
Hilf G, et al. [See Related Articles]
Agonist-independent inhibition of G protein activation by muscarinic
acetylcholine receptor antagonists in
cardiac membranes.
Eur J Pharmacol. 1992 Mar 12; 225(3): 245-252.
PMID: 1516656; UI: 92387316.
Khazipov RN, et al. [See Related Articles]
[Effect of magnesium ions on the functional state of postsynaptic
membrane by modulation of the level of
non-quantal secretion of the mediator].
Neirofiziologiia. 1992; 24(1): 97-100. Russian.
PMID: 1584312; UI: 92261736.
Giniatullin RA, et al. [See Related Articles]
[Effect of the quantal composition, membrane potential and
cholinoreceptor density on the temporal flow of the
end plate current in the rat under conditions of
acetylcholinesterase inhibition].
Neirofiziologiia. 1992; 24(3): 269-279. Russian.
PMID: 1513401; UI: 92382672.
Braga MF, et al. [See Related Articles]
Effects of tacrine, velnacrine (HP029), suronacrine (HP128), and
3,4-diaminopyridine on skeletal
neuromuscular transmission in vitro.
Br J Pharmacol. 1991 Apr; 102(4): 909-915.
PMID: 1649660; UI: 91308896.
Yang CM, et al. [See Related Articles]
Down-regulation of muscarinic receptors in the striatum of
organophosphate-treated swine.
Toxicol Appl Pharmacol. 1990 Jul; 104(3): 375-385.
PMID: 2385834; UI: 90350123.
Hurlbut WP, et al. [See Related Articles]
Correlation between quantal secretion and vesicle loss at the frog
neuromuscular junction.
J Physiol (Lond). 1990 Jun; 425: 501-526.
PMID: 2120425; UI: 91012193.
Perelman A, et al. [See Related Articles]
Differential association and distribution of acetyl- and
butyrylcholinesterases within rat liver subcellular
organelles.
J Biol Chem. 1990 Jan 5; 265(1): 214-220.
PMID: 2152920; UI: 90094401.
Szabolcs M. [See Related Articles]
Enzymatic properties, metal composition and SH-group reactivity of
fragmented sarcoplasmic reticulum
isolated from rabbit skeletal muscle.
Acta Biochim Biophys Hung. 1990; 25(1-2): 111-124.
PMID: 1966646; UI: 92024654.
Endres W, et al. [See Related Articles]
Acetylcholinesterase reactivators antagonize epileptiform bursting
induced by paraoxon in guinea pig
hippocampal slices.
J Pharmacol Exp Ther. 1989 Dec; 251(3): 1181-1186.
PMID: 2600810; UI: 90095866.
Best of results,
Chuck
