Please note the change in program for the symposium on "Molecular models for
prediction of drug metabolism and toxicity", on 19 April.
S Kliewer, USA Use of the nuclear receptors PXR and PPAR to predict drug
toxicity
P Ortiz de Montellano, USA Model based prediction of drug metabolism;
lessons from bacterial and mammalian enzymes
G C K Roberts, UK The use of structural information from NMR to improve
active-site models of cytochromes P450
M Parker, Australia Three-dimensional structures of glutathione
transferases and their interactions with drugs
B Houston, UK Prediction of rates of metabolism; in vitro to in vivo
extrapolation
The British Toxicology Meeting 18-21 April has the following sessions.
See
http://www.bts.org/
Molecular models for prediction of metabolism and toxicity
Current issues in pharmaceutical regulatory toxicology
Inflammatory cells and mediators in immunotoxic and allergic responses
Same dose, different person; biomarkers of individual exposures to toxic
agents
The limits of toxicity testing in man
Molecular biology in pathology and toxicology
Occupational toxicology: controversies on carcinogenicity
Barnes lecture A. Wyllie, UK: Mutagenesis, apoptosis and cancer treatment
Oral communications
Early markers of cell death in toxicity testing
Challenges associated with the safety evaluation of products from transgenic
animals and plants
David R Bell
