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Acetaminophen

Chris Evelo C.Evelo at Farmaco.UniMaas.nl
Tue Mar 16 04:23:11 EST 1999


Not acetaminophen but one of its metabolites is responsible for the
lipid peroxidation. To test this your testsysteem should be able to form
this metabolite.

papakos at ibm.net wrote:
> 
> Does anybody know what lipid changes acetaminophen induces
> in liver or kidneys?
> I have read that APAP augments lipid peroxidation at concentrations:
> 0.5 to 5.0 mM BUT
> when i tested the compound i found no lipid peroxides usind 1 mM within 5
> hours incubation time?
> Any suggestions?
> 
> A Scientist

-- 
 Dr.Ir. Chris T.A. Evelo PhD
 Department of Pharmacology & Toxicology; Universiteit Maastricht
 P.O. Box 616; NL-6200 MD Maastricht; The Netherlands
  
 tel: +31-43-3881231 +31-43-3881417;  fax: +31-43-3670940
 email: C.Evelo at Farmaco.UniMaas.nl



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