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Lidocaine metabolites immunoactive? (Was: Re: Local anesthetic a carcinogen (Was: Re: Amalgam study))

Brian Sandle bsandle at southern.co.nz
Tue Oct 26 19:41:56 EST 1999


In sci.med.dentistry Brian Sandle <bsandle at southern.co.nz> wrote:
: In sci.med.dentistry Brian Sandle <bsandle at southern.co.nz> wrote:: :   Carcinogenesis 1994 Oct;15(10):2287-90
: : :   
: : :2,6-Dimethylaniline--hemoglobin adducts from lidocaine in humans.
: : : 
: : :    Bryant MS, Simmons HF, Harrell RE, Hinson JA
: [...]
: : J Autoimmun 1995 Apr;8(2):293-303
: :  
: : Autoantibodies to cryptic epitopes of C-reactive protein and other acute
: : phase proteins in the toxic oil syndrome.
: :  
: : Bell SA, Du Clos TW, Khursigara G, Picazo JJ, Rubin RL
: :  
: : Toxic oil syndrome (TOS) was caused by the consumption of rapeseed oil
: : contaminated with derivatives of aniline. Many persons who survived the
: : acute phase developed a puzzling, multi-year chronic disease considered to
: : be inflammatory or autoimmune in nature.
: [...]
: Lidocaine can be immediately a problem for some people. An allergic 
: reaction occurs. But could there be a longer term problem caused by 
: aniline metabolites of lidocaine?

Now does Lidocaine cross into to embryonic or fetal blood?

Do lidocaine metabolites pass over?

Does the embryo or fetus have the same risk of allergenicity or aniline 
toxicity as the mother?

What is more dangerous, amalgam or aniline?



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