On Wed, 27 Oct 1999, c. miller wrote:
> Date: Wed, 27 Oct 1999 09:41:45 -0600
> From: c. miller <rellim at mailhost.tcs.tulane.edu>
> To: toxicol at net.bio.net, bsandle at kalessin.southern.co.nz> Subject: Lidocaine, immunotoxicity, and chronic diseases?
>>> Brian Sandle posed some interesting questions about lidocaine metabolism,
> dimethylaniline, immunoreactivity, and chronic disease(s) below.
>> I was wondering about the titers of aniline-albumin, aniline-hemoglobin (or
> other protein) antibodies following lidocaine anesthesia. Are they
> detectable? Is there an anti-idiotypic response as well?
>> Aniline is a reasonably good hapten. Perhaps following lidocaine treatment
> (and its metabolism) as the primary immune challenge, it seems possible
> that aniline (or related compounds) exposure could be common enough of an
> environmental factor to perpetuate some level of chronic immune response
> (at least in some people).
Searching the databases for various combinations of
cognitive affective prenatal perinatal birth anesthetic epidural
lidocaine bupivacaine
shows some adverse effects in infancy of prenatal or perinatal
anesthetic exposure.
Here are a few refs from Medline and one abstract from PsycLit
Title
Central administration of cocaine produces age-dependent
effects on behavior in the fetal rat.
Author(s)
Simonik-D-K; Robinson-S-R; Smotherman-W-P
Source Journal
Behavioral Neuroscience 108(6): 1179-1187
Publication Year
1994
TITLE
Prenatal lidocaine and the auditory evoked responses in term
infants [published erratum appears in Am J Dis Child 1988
Aug;142(8):846]
AUTHOR(S)
Diaz-M; Graff-M; Hiatt-IM; Friedman-S; Ostfeld-B; Hegyi-T
SOURCE (BIBLIOGRAPHIC CITATION)
Am-J-Dis-Child.1988 Feb; 142(2): 160-1.
TITLE
Lack of effects of prenatal exposure to lidocaine on
development of behavior in rats.
AUTHOR(S)
Teiling-AK; Mohammed-AK; Minor-BG; Jarbe-TU; Hiltunen-AJ;
Archer-T
SOURCE (BIBLIOGRAPHIC CITATION)
Anesth-Analg.1987 Jun; 66(6): 533-41.
[...]However, in
the schedule of differential reinforcement of low rates of
responding (DRL 20), the lidocaine-exposed males received more
reinforcements than the controls and made fewer responses.[...]
TITLE
Behavioral effects of mid-pregnancy administration of lidocaine
and mepivacaine in the rat.
AUTHOR(S)
Smith-RF; Wharton-GG; Kurtz-SL; Mattran-KM; Hollenbeck-AR
SOURCE (BIBLIOGRAPHIC CITATION)
Neurobehav-Toxicol-Teratol.1986 Jan-Feb; 8(1): 61-8.
[...]These data demonstrate that
midgestational exposure to lidocaine or mepivacaine at a dose
near the limits of permissible human exposure produces
significant behavioral changes in the offspring. This
preliminary study suggests that development of some portion of
the central nervous system is altered by such exposure. Further
work is required to determine the parameters and the extent of
the effect.
TITLE
Behavioral effects of prenatal exposure to lidocaine in the
rat: Effects of dosage and of gestational age at
administration.
AUTHOR
Smith,-Robert-F.; Kurkjian,-Maura-F.; Mattran,-Kathleen-M.;
Kurtz,-Steven-L.
SOURCE
Neurotoxicology-and-Teratology.1989 Jul-Aug; Vol 11(4):
395-403.
ABSTRACT
Pregnant rats dosed via injections into the gum with 3, 6, or 9
mg/kg lidocaine or administered vehicle or uninjected on
Gestational Day 4 (GD4), GD11, or GD18 produced offspring (8-21
litters/group) that were tested for behavioral development and
adult behavior. At GD4, only footshock sensitivity showed a
significant effect of dosing. For administration on GD11,
lidocaine was associated with slight but significant
alterations in sex ratios and a trend toward effects on
development of spontaneous alternation. Lidocaine dosing on
GD18 was associated with a number of significant alterations of
behavior, including visual discrimination, shuttlebox
avoidance, tailflick, and water maze errors; there were also
both vehicle and lidocaine effects on water maze latencies.
Lidocaine may be a behavioral teratogen. ((c) 1999
APA/PsycINFO, all rights reserved)
In sci.med.dentistry Brian Sandle <bsandle at southern.co.nz> wrote:
: In sci.med.dentistry Brian Sandle <bsandle at southern.co.nz> wrote:
: : Now does Lidocaine cross into to embryonic or fetal blood?
: : Do lidocaine metabolites pass over?
: : Does the embryo or fetus have the same risk of allergenicity or aniline
: : toxicity as the mother?
: : What is more dangerous, amalgam or aniline?
: Now quite a few people have their amalgam fillings removed and replaced
: with composite. Not all of them get any better. Also a number of people
: report feeling unwell after a dental visit.
: I wonder if the aniline metabolites from the anaesthetic has been a problem
: for a lot. Besides composite trouble, that is.
