FW: NIEHS and SOT Sponsored Genomic Data in Risk Assessment Workshop/ Nov.2001

Charles Miller rellim at tulane.edu
Fri Jul 6 11:07:22 EST 2001

Dear Colleague:
Please find below information on an NIEHS/SOT sponsored workshop that
will be held in November.  Further information is given  at the URL
cited below

Mike McClure/NIEHS
Use of Genomic Data in Risk Assessment: State of the Art 2001
Sponsored by: National Institute of Environmental Health Sciences
and the Society of Toxicology Risk Assessment Task Force
Washington, D.C., 7-8 November, 2001

For more information see:

Organizing Committee Members:
Michael L. Cunningham    NIEHS
Tim Zacharewski     MSU
Ron Hines     MCW
Matt Bogdanffy     DuPont
Focus and Objectives:
Recent advancements in genomics (the global analysis of genes and
their expression) have set the stage for understanding the adaptive
and toxicological responses of individuals after exposure to toxic
insults.  It is now possible to simultaneously assess the levels of
expression of thousands of different genes using DNA microarrays.
With the completion of the Human Genome Project, it will be possible
to analyze the expression of all genes transcribed in a specific cell.
The risk of causing a disease by toxicant exposure used to be
estimated across populations with widely varying responses resulting
from each individuals unique genetic  make-up (toxicogenomics).  In the
21st century, the new genomic technologies will greatly improve the
accuracy of risk assessment, allowing identification of sensitive
subpopulations at risk and ultimately resulting in a personalized
risk profile for each individual based on their genetic composition.
This workshop will examine these genomic technologies and the
implications for risk characterization and understanding of
gene-environment  interactions. Complex social, moral, and legal
issues raised by the project relating to the protection of human
subjects, the privacy of genetic  information, and the possibility of
discriminatory uses of the data generated by the project  are also

Michael E. McClure, Ph.D.
Chief, Organs and Systems Toxicology Branch
Tele: 919-541-5327
Division of Extramural Research and Training
Fax: 919-541-5064
National Institute of Environmental Health Sciences, NIH
E-Mail:  mm461n at nih.gov
111 T.W. Alexander Drive
Courier: 79 T.W. Alexander Dr
P.O. Box 12233, Mail Drop EC-23
Bldg. 4401, Rm. 3417
Research Triangle Park, North Carolina 27709
RTP. NC 27709


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