LSRO report

Daniel Byrd byrdd at cox.net
Thu Jul 1 09:44:50 EST 2004

The Life Sciences Research Office (LSRO) has released a new report, The 
Feasibility of Testing Ingredients Added to Cigarettes.

A National Academy of Sciences Institute of Medicine report in 2001, 
Clearing the Smoke, recommended that manufacturers test ingredients 
added to cigarettes.  However, that report did not contain sufficiently 
detailed information about how to test ingredients.  Philip Morris USA, 
a manufacturer of cigarettes, tasked LSRO, a nonprofit, scientific 
research organization, with supplying the additional details.  LSRO 
assembled a multidisciplinary advisory panel and divided the project 
into three phases:

	(1) the feasibility of testing ingredients,
	(2) the scientific criteria to apply in testing ingredients, and
	(3) reviews of specific ingredients.

The members of LSRO’s ad-hoc expert panel are:

Carroll E. Cross, M.D.					Shayne C. Gad, Ph.D., D.A.B.T.
     Sacramento, CA						Cary, NC
Donald E. Gardner, Ph.D., F.A.T.S.		Louis D. Homer, M.D., Ph.D.
     Raleigh, NC					    			Portland, OR
Rudolph J. Jaeger, Ph.D., D.A.B.T. 		Robert Orth, Ph.D.
     Westwood, New Jersey				Cedar Hill, MO
Resha M. Putzrath*, Ph.D., D.A.B.T.		Emanuel Rubin, M.D.
     Washington, DC						Philadelphia, PA
James L. Schardein, M.S. F.A.T.S.		Thomas J. Slaga, Ph.D.
     Leesburg, FL					    	Denver, CO

Cigarettes are, by definition, made from tobacco and paper only. 
Cigarette smoking creates known adverse human health risks.  A 
nontobacco ingredient added to a cigarette could increase these risks. 
Relative risk compares the risk of smoking cigarettes with an added 
ingredient to the risk of smoking cigarettes without the ingredient. 
Relative risk could change after adding a nontobacco ingredient in three 
ways: (1) The ingredient could transfer in the smoke, be inhaled, and 
cause an adverse effect.  In addition, the ingredient could undergo a 
change in chemical structure, as a result of concurrent tobacco 
combustion, and the resulting pyrolysis products could transfer into the 
smoke.  (2) The chemical composition of the tobacco smoke could change, 
increasing the known adverse health effects of smoking.  (3) Exposure to 
cigarette smoke constituents could change, though a change in smoking 
behavior.   A person could smoke more cigarettes or smoke the same 
number more intensely.

To prepare the report, LSRO’s staff and its advisors reviewed papers and 
from the published scientific literature.  LSRO also solicited public 
comments and held an open meeting in August 2002 to discuss the pending 
report.  The report concludes that a review of the effects of the 
nontobacco ingredients added to cigarettes, while challenging, is 
feasible, scientifically achievable, and potentially worthwhile as a 
public health objective.  Because chapter five provides detailed 
information about adverse human health effects of cigarette smoking, the 
report may interest toxicol at net.bio.net subscribers.  In addition, other 
chapters cover smoke generation, exposure, dosimetry, and testing.

LSRO’s reports provide information, analysis, and advice about 
fundamental issues in areas such as medicine, health care, nutrition, 
food safety, and the environment.  LSRO is located at 9650 Rockville 
Pike, Bethesda, MD  20814-3998.  For further technical information, 
please contact Daniel Byrd, Ph.D., D.A.B.T., at (301)634-7030.  Copies 
of the publication may be obtained from LSRO at 9650 Rockville Pike, 
Bethesda, MD  20814-3998 or from the LSRO net site (www.lsro.org).

*/ Through July 2003

Daniel M. Byrd III, Ph.D., D.A.B.T.
8370 Greensboro Drive, Apt. 708
McLean, VA  22102
byrdd at cox.net


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