Fwd: Harmonized TCE PBPK Model Peer Consultation

Charles Miller rellim at tulane.edu
Fri May 14 11:50:19 EST 2004

Begin forwarded message:

> From: Jacqueline Patterson <patterson at TERA.ORG>
> Date: May 14, 2004 9:46:33 AM CDT
> Subject: Harmonized TCE PBPK Model Peer Consultation
> Reply-To: General Toxicology Discussions <TOXLIST at ESC.SYRRES.COM>
> Toxicology Excellence for Risk Assessment (TERA) is conducting a peer
> consultation on June 29, 2004 in Cincinnati Ohio to discuss a 
> harmonized
> physiologically-based pharmacokinetic (PBPK) model for 
> trichloroethylene
> (TCE).  A panel of experts in PBPK modeling and TCE kinetics and
> metabolism will meet for the purposes of soliciting expert advice on 
> how
> to improve the draft model.  TERA, a non-profit organization, is
> convening this meeting, which will be open to the public.  More
> information on the peer consultation will be available shortly at
> http://www.tera.org/vera/TCE%20announcement.htm.
> Background
> Currently, there is no single PBPK model that incorporates the full
> range of available science and data on the pharmacokinetics of TCE and
> its metabolites.  Scientific teams led by Dr. Jeffrey Fisher and Mr.
> Harvey Clewell have each developed one or more PBPK models for TCE and
> its metabolites.  These models have different structures both in terms
> of their tissue compartments as well as in their metabolic pathways and
> are based on largely independent data sets.
> The U.S. Air Force (USAF) and the U.S. Environmental Protection Agency
> (EPA) are jointly sponsoring a scientific workgroup to develop a
> harmonized PBPK model for TCE and its metabolites based on the full
> range of available science and data.  This workgroup is composed of
> scientists from the USAF and EPA, with technical expertise from TERA 
> and
> scientists such as Dr. Fisher and Mr. Clewell under contract to the
> USAF.  The results of this joint USAF-EPA workgroup will serve as
> important input to ongoing TCE risk assessment activities, including a
> planned multi-agency consultation with the National Academy of Sciences
> on TCE science issues as well as EPA's revised TCE human health risk
> assessment.  No conclusions as to the human health risks of TCE 
> exposure
> are being developed as part of this project; and no judgments as to 
> what
> should or should not be used in risk assessment are being made.
> Contacts:
> Dr. Jay Zhao, TERA, 513-542-7475, ext. 16
> Dr. Michael Dourson, TERA, 513-542-7475, ext. 14
> Jacqueline Patterson, M.En.
> Peer Consultation and Review Program Manager
> Toxicology Excellence for Risk Assessment (TERA)
> NEW TERA address effective April 30, 2004
> 2300 Montana Avenue
> Suite 409
> Cincinnati, OH 45211
> 513-521-7426 phone
> 513-542-7487 fax
> patterson at tera.org
> www.tera.org
Charles A. Miller III, Ph.D.
Environmental Health Sciences Department
Room 374 J.B. Johnston Bldg.
Tulane Univ. School of Public Health and Tropical Medicine
1430 Tulane Ave.
New Orleans, LA 70112
504-585-6942, rellim at tulane.edu
Web page: http://home.bellsouth.net/p/PWP-chuckmiller
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