short review: research on aspartame (methanol, formaldehyde, formic acid): Murray 2005.04.09

Rich Murray rmforall at att.net
Sun Apr 10 22:07:48 EST 2005


short review: research on aspartame (methanol, formaldehyde, formic acid):
Murray 2005.04.09

Rich Murray, MA  Room For All  rmforall at comcast.net  505-501-2298
1943 Otowi Road    Santa Fe, New Mexico 87505   USA
group with 180 members, 1,165 posts in a public, searchable archive

research on aspartame (methanol, formaldehyde, formic acid) toxicity: Murray
2004.04.29 rmforall

methanol (formaldehyde, formic acid) disposition: Bouchard M et al, full
plain text, 2001: substantial sources are degradation of fruit pectins,
liquors, aspartame, smoke: Murray 2005.04.02 rmforall

Aspartame (NutraSweet, Equal, Canderel, E951), after eight years of
controversy, was suddenly and capriciously approved by a new FDA
commissioner,  Arthur Hull Hayes, Jr,  just appointed by President Reagan, a
pharmacologist who had been in office less than three months and had little
background in food additives, in July 1981, overturning the vote of his own
Scientific Board of Inquiry.

Aspartame is made of phenylalanine (50% by weight) and aspartic acid (39%),
both ordinary amino acids, bound loosely together by methanol (wood alcohol,
11%).   The readily released methanol from aspartame is within hours turned
by the liver into formaldehyde and then formic acid, both potent, cumulative

A team in a Searle Co. lab, led by J.A. Oppermann proved that 30% of the
methanol in aspartame fed to rats remained, indubitably as toxic products of
formaldehyde and formic acid in all tissues (1973, 1976).

aspartame puts formaldehyde adducts into tissues, Part 1/2
full text, Trocho & Alemany 1998.06.26: Murray 2002.12.22 rmforall

This was confirmed by an expert team at the University of Barcelona (Trocho,
Alemany et al, 1998):
"...the binding of methanol-derived carbon to tissue proteins was
widespread, affecting all systems, fully reaching even sensitive targets
such as the brain and retina...These are indeed extremely high levels for
adducts of formaldehyde, a substance responsible for chronic deleterious
effects (33), that has also been considered carcinogenic (33,47)."

Fully 11% of aspartame is methanol--  1,120 mg aspartame  in 2 L diet soda,
almost six 12-oz cans,  gives 123 mg methanol (wood alcohol).   If 30% of
the methanol is turned into formaldehyde, the amount of formaldehyde is 18
times the EPA limit for daily formaldehyde in drinking water, 2 mg in 2 L

President Bush & formaldehyde (aspartame) toxicity: Ramazzini Foundation
carcinogenicity results Dec 2002: Soffritti: Murray 2003.08.03 rmforall

p. 88 "The sweetening agent aspartame hydrolyzes in the gastrointestinal
tract to become free methyl alcohol, which is metabolized in the liver to
formaldehyde, formic acid, and CO2. (11)"   Medinsky MA & Dorman DC. 1994;
Assessing risks of low-level methanol exposure. CIIT Act. 14: 1-7.

Ann N Y Acad Sci. 2002 Dec; 982: 87-105.
Results of long-term experimental studies on the carcinogenicity of
formaldehyde and acetaldehyde in rats.   M. Soffritti et al.  Cancer
Research Center, European Ramazzini Foundation for Oncology and
Environmental Sciences, Bologna, Italy. crcfr at tin.it

eight depressed people react strongly to aspartame, Prof. Ralph G. Walton,
MD, 1993 double-blind study, full text: Murray 2004.04.26 rmforall
Despite the very small number of subjects, the results were dramatic and
statistically significant.  The eight depressed patients reported with
aspartame, compared to placebo, much higher levels of nervousness, trouble
remembering, nausea, depression, temper, and malaise.

Many scientific studies and case histories report:  * headaches  * many body
and joint pains (or burning, tingling, tremors, twitching, spasms, cramps,
stiffness, numbness, difficulty swallowing)  *  fever, fatigue, swollen
glands  * "mind fog", "feel unreal", poor memory, confusion, anxiety,
irritability, depression, mania, insomnia, dizziness, slurred speech, sexual
problems,  poor vision, hearing (deafness, tinnitus), or taste  * red face,
itching, rashes, allergic dermatitis, hair loss, burning eyes or throat, dry
eyes or mouth, mouth sores, burning tongue  * obesity, bloating, edema,
anorexia, poor appetite or excessive hunger or thirst    * breathing
problems, shortness of breath * nausea, diarrhea or constipation  * coldness
* sweating  * racing heart, low or high blood pressure, erratic blood sugar
levels  * hypothryroidism or hyperthyroidism  * seizures  * birth defects
*  brain cancers  * addiction  * aggrivates diabetes, autism, allergies,
lupus, ADHD, fibromyalgia, chronic fatigue syndrome, multiple chemical
sensitivity, multiple sclerosis, pseudotumor cerebri and interstitial
cystitis (bladder pain).

Donald Rumsfeld, 1977 head of Searle Corp., got aspartame FDA approval:
Turner: Murray 2002.12.23 rmforall

Mark Gold exhaustively critiques European Commission Scientific Committee on
Food re aspartame ( 2002.12.04 ): 59 pages, 230 references

genotoxicity of aspartame in human lymphocytes 2004.07.29 full plain text,
Rencuzogullari E et al, Cukurova University, Adana, Turkey 2004 Aug: Murray
2004.11.06 rmforall

Murray, full plain text & critique: chronic aspartame in rats affects
memory, brain cholinergic receptors, and brain chemistry, Christian B,
McConnaughey M et al, 2004 May: 2004.06.05 rmforall

eyelid contact dermatitis by formaldehyde from aspartame, AM Hill & DV
Belsito, Nov 2003: Murray 2004.03.30 rmforall

continuing aspartame debate in British Medical Journal, John Biffra, Bob
Dowling, Nick Finer, Ian J Gordon: Murray 2005.02.09 rmforall

politicians and celebrities hooked on diet sodas (aspartame): Murray
2004.03.24 rmforall

http://google.com  gives 468,000 websites for "aspartame" , with the top 7
of 10 listings being anti-aspartame, while
http://www.ncbi.nlm.nih.gov/PubMed   lists 784 aspartame items.

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