IUBio

ageing/caloric restriction

janapati at ouvaxa.cats.ohiou.edu janapati at ouvaxa.cats.ohiou.edu
Thu May 19 17:23:04 EST 1994


So far the only way to prolong the lifespan was found to be caloric restriction at an early stage of life.  But the mechanism by which the lifespan is extended is not known.  Some believe it to be due to reduced metobolic rate and decrease in free radical production and damage.  Where as others believe that a change in the levels of hormones in the blood.  Free radicals damage is now found to beinvolved in several degenerative diseases.  Free radical production was found to be only the terminal event in th

e
 disease process.  Moreover trophic factors are found to reverse degenerative changes in neurons.  From these studies, it implies that changes in hormone or trophic factor levels or in signal transduction mechanism might be responsible for senescence.




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