Telomeric Theory - Research Proposals

Aubrey de Grey ag24 at mole.bio.cam.ac.uk
Mon Nov 16 08:48:41 EST 1998

Robert Ames wrote:

> Is there any rational strategy for determining the optimal mix of
> antioxidants?

For retarding aging?  My own view is that antioxidant supplementation
cannot much retard aging of homeotherms (warm-blooded animals), because
the process that I consider most likely to be the major rate-determinant
of homeotherm aging is probably impervious to antioxidants.  (For details
see my BioEssays and JAAM papers; in a nutshell, I propose that the rate
of damage to the inner mitochondrial membrane is central and is largely
governed by the levels of superoxide in the mitochondrial intermembrane
space, where there is no superoxide dismutase.)

For other benefits -- defence against disease without extending maximum
lifespan potential -- the situation is very different and others here are
much more knowledgeable than I.

Aubrey de Grey

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