Thermodynamics of aging

Georgi P. Gladyshev academy at ENDEAV.ORG
Mon Nov 23 12:58:03 EST 1998

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Subject: AGING,ORIGIN OF LIFE, Supramolecular chemistry and
thermodynamics of biological evolution and aging, Supramolecular
thermodynamics, Complex systems, Thermodynamics of origin of life,
Macrothermodynamics, Self-assembly of supramolecular structures,
Supramolecules and Assemblies, Adaptation

For professional scientists!
Dear Colleagues,
I would be much obliged to you if you could take a look at my web site.
My Institute: URL http://www.endeav.org/evolut ,
Georgi P. Gladyshev

Thermodynamics of Aging
(The general theory of Aging)

The aim of this paper is: to find out, from the view point of general
lows of Nature, why we age and  find the ways of slowing down the

   (Materials for the Symposium “Thermodynamics and Information Theory
in Biology” – 1998  AAAS Annual Meeting and Science Innovation
Exposition AAAS’s 150-th Anniversary Celebration, Track: Emerging
Science: Transforming the Next Generation)


  The findings of macrothermodynamics (supramolecular thermodynamics) of
quasi-closed systems and the published data about the variation of the
chemical composition of living organisms in  ontogeny confirm the
thermodynamic tendency of aging processes. According to the
thermodynaic  theory the specific value of the Gibbs function of the
formation of supramolecular structures of the organism tends to a
minimum. That tendency explains the variation of the supramolecular and
 chemical composition and the morphology of tissues during aging. The
theory makes it possible to  define the principles upon which proper
diets and medications can be devised to slow down aging.    Such diets
and medications are also useful in preventative care and in the
treatment of various    pathologies and among them those attending old
age. The principle of the stability of chemical  substance of the
supramolecular structures of tissues makes it possible to understand the
causes of
 the practically unlimited evolution of the biological world from the
perspective of the Second Law in its classical definition.
 The  full text of paper at: http://www.endeav.org/evolut/text/ta/ta.htm

and see also (the information about my book and others papers ):
New    http://www.endeav.org/evolut/text/mf/index.htm


There are two main questions.

The first question:  Why We Age ?  -   Now we know only one theory. It
is the thermodynamic theory.
The second question:  How We  Age ?    -    A lot of theories which  are

connected with kinetics and mechanisms of processes .
One can propose a lot of the characteristic (particularistic) factors
are connected with the mechanisms of aging of some living structures.
See for example: Ronald Klatz, Robert Goldman, Stopping the Clock, Keats
Publ. INC, New Canaan, Connecticut, 1996, 370 pp.

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