BioGerontology Congress: Interesting Abstracts and Extended Deadline (* July 10 ! *)

Leonid Gavrilov lagavril at midway.uchicago.edu
Fri Jul 4 07:44:35 EST 2003

Thank you very much !

Please note that the deadline for Abstract Submission and 
early-discount registration for the Biomedical Gerontology Congress 
is extended until July 10 !

Kind regards,

-- Leonid Gavrilov 
Author of the book "The Biology of Life Span" 

tcarter2 at elp.rr.com (Thomas Carter) wrote in message news:<a7b55247.0306280939.27b6368b at posting.google.com>...
> lagavril at midway.uchicago.edu (Leonid Gavrilov) wrote in message news:<pgpmoose.200306231124.4532 at net.bio.net>...
> > Greetings,
> > 
> > I have found useful weblink to many interesting abstracts for the
> > forthcoming 10th Congress of the International Association of
> > Biomedical Gerontology (England, September 2003):
> > 
> > http://www.gen.cam.ac.uk/iabg10/abslist.htm
> > 
> > What is particularly encouraging --  the deadline for abstract
> > submission and early discount registration is extended until this
> > Friday, June 27.
> > 
> > Perhaps this information may be interesting to you.
> > 
> > Kind regards,
> > 
> > -- Leonid Gavrilov 
> > Senior Member of the Science Advisory Board 
> > (http://www.scienceboard.net/)
> Hi Leonid,
>       Many thanks for this post. I've spent the last week studying the
> abstracts and am still not finished. Surely the IABG is the number one
> organization in the field and I look forward to the publishing of the
> papers every year. These abstracts by the most immanent scientists in
> biogernontology touch on every aspect of aging and serve as both a
> good review of the past year and a preview of the year to come. I
> suppose those of most general interest will be once again published as
> a volume of the annals of the NYAS. I hope it will also be available
> for a while in full text like last year. BTW I have found the search
> string below to be useful. It can be browsed for an historical
> perspective or it can be "ANDed" with a subject of interest to see how
> it relates to aging. It returns some papers of the last six IABG
> congresses.
> (Ann N Y Acad Sci AND (959[vol] OR 928[vol] OR 854[vol] OR 786[vol] OR
> 717[vol] OR  673[vol])). For those who would like to see what a clean
> shaven Aubrey has been upto lately click on home (of Leo's link) and
> then on SENS and nearby links. He certainly isn't shy about tackling
> tuff projects.
>      I have selected just one of the many interesting abstracts and
> attached it below, as it bears on what seems to be a most promising
> intervention available to us now. My second attachment suggests a
> possible synergism between Yokozawa T's two groups.
> Thomas
> Interventions in aging and age-associated pathologies by means of
> nutritional approaches K. Kitani, T. Yokozawa, T. Osawa National
> Institute for Longevity Sciences, 36-3, Gengo, Moriokacho, Obu-shi,
> Japan 4748522
>          The "Free Radical Theory of Aging" (FRTA) initially proposed
> by Harman [1]) half a century ago has been increasingly supported in
> recent years. However, while there have been a number of studies
> demonstrating a significant effect of antioxidant treatment in
> preventing experimentally induced pathologies that are believed to be
> at least partially caused by oxygen induced tissue damage, so-called
> antioxidant strategies have not been shown convincingly to be
> effective in increasing life spans of animals [2]). Accordingly, the
> general consensus of experimental gerontology in the last century was
> "The only reproducible means of prolonging survivals of animals is the
> calorie restriction paradigm." As a challenge against this dogma, we
> attempted to examine the effect of two potent antioxidants, one
> tetrahydrocurcumin (TC), a biotransformed metabolite of curcumin
> contained in turmeric of Indian curry, and the other green tea
> polyphenols (PPs). Male C57L/6JNia (Harlan-Sprague Dawley, Ind.) began
> to receive treatments at the age of 13 months. In the TC experiment,
> animals received TC containing pellets (0.2%) or standard pellets (MF,
> Oriental Ltd., protein 24%). In the PPs experiment, animals received
> normal diets (MF) and normal drinking water or water containing green
> tea water extract product (Sunphenon 100S, Taiyokagaku, Yokkaichi,
> Japan) containing various PPs ( EQ70%) at a concentration of 80 mg/l
> both pasteurized by g ray irradiation. Survivals of animals were
> examined until deaths of these animals. Average life span (days) in TC
> fed mice was 11.7% longer (882.2 1154.6, mean 1 S.D.) than in control
> mice (797.6 1 151.2, both n=50) (P<0.01). The 10% longest survival was
> also significantly greater (+6.5%, each n=5, P<0.05) in TC fed
> animals. The increase in average life expectancy after 24 months of
> age as calculated by including mice that died before 24 months as
> negative days was 125.9 %. Similarly, in PPs fed mice, the average
> life span increased by 6.4%, (801.1 1 121.5, 852.7 1 88.2, control vs.
> PP fed mice, each n=50, P<0.01). The increase in average life
> expectancy after 24 months was 72.6%. Body weights of TC fed animals
> were slightly (4~6%) but significantly (P<0.05) lower compared with
> those in control mice in the first 6 months of treatments. Thereafter
> the difference was totally lost. In PP fed mice, average body weights
> were almost identical to those in control mice throughout the
> observation periods. Most of past attempts including that by Lipman
> and coworkers [2]) by nutritional means have failed in achieving a
> statistically significant prolongation of life spans of animals.
> However, as shown in the present study, some nutriceuticals appear to
> have potential of significantly increasing life spans of animals. Both
> nutriceuticals have been shown to be effective in preventing a number
> of experimentally induced age associated disorders including cancer,
> atherosclerosis and others. Furthermore, the advantage of these agents
> is the least toxic nature to humans which has been confirmed in human
> experimentation of thousands of years. Since these agents are known to
> be effective in preventing atherosclerosis which does not involve wild
> type rodents but is the number one killer of elderly humans, it is
> expected that supplementation of these agents may be effective for
> prolonging the life span (at least health span) of humans possibly
> more effectively than observed in rodents. In conclusion, nutritional
> approaches in prolonging the health span (if not life span) of humans
> may be more promising than believed before and deserves further
> extensive study using nutriceuticals possessing antioxidant
> properties. References
> 1) Harman D. J. Gerontol. 12:257-263, 1956
> 2) Lipman RD et al. Mech Ageing Dev 103:269-284, 1998 
> Key words: mice, life span, tetrahydrocurcumin, green tea polyphenol,
> antioxidants
> Quantitation of chemopreventive synergism between
> (-)-epigallocatechin-3-gallate and curcumin in normal, premalignant
> and malignant human oral epithelial cells.
> Khafif A, Schantz SP, Chou TC, et al. Carcinogenesis 1998;19:419-424.
> An in vitro model for oral cancer was used to examine the growth
> inhibitory effects of chemopreventive agents when used singly and in
> combination. The model consists of primary cultures of normal oral
> epithelial cells, newly established cell lines derived from dysplastic
> leukoplakia and squamous cell carcinoma. Two naturally occurring
> substances, (-)-epigallocatechin-3-gallate (EGCG) from green tea and
> curcumin from the spice turmeric were tested. Cells were treated
> singly and in combination and effects on growth determined in 5-day
> growth assays and by cell cycle analysis. Effective dose 50s and the
> combination index were calculated with the computerized Chou-Talalay
> method which is based on the median-effect principle. Agents were
> shown to differ in their inhibitory potency. EGCG was less effective
> with cell progression; the cancer cells were more resistant than
> normal or dysplastic cells. In contrast, curcumin was equally
> effective regardless of the cell type tested. Cell cycle analysis
> indicated that EGCG blocked cells in G1, whereas curcumin blocked
> cells in S/G2M. The combination of both agents showed synergistic
> interactions in growth inhibition and increased sigmoidicity
> (steepness) of the dose-effect curves, a response that was dose and
> cell type dependent. Combinations allowed for a dose reduction of
> 4.4-8.5-fold for EGCG and 2.2-2.8-fold for curcumin at ED50s as
> indicated by the dose reduction index (DRI). Even greater DRI values
> were observed above ED50 levels. Our results demonstrate that this
> model which includes normal, premalignant and malignant oral cells can
> be used to analyse the relative potential of various chemopreventive
> agents. Two such naturally-occurring agents, EGCG and curcumin, were
> noted to inhibit growth by different mechanisms, a factor which may
> account for their demonstrable interactive synergistic effect.

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