Post-doctoral position available immediately

fzrjorge at BULLWINKLE.UCDAVIS.EDU fzrjorge at BULLWINKLE.UCDAVIS.EDU
Tue Aug 31 19:50:14 EST 1993


flower pigmentation patterns which are based on "co-suppression" of chalcone 
synthase genes (a CHS transgene and the two endogenous CHS genes).  Patterns 
are determined by one or more cell-type-specific factors which appear to 
interact with the transgene.  The endogenous CHS gene acts as a reporter 
gene, being silenced by expression of the transgene.  Cells determining 
pattern include cells at the junctions between petals, cells at the corolla 
edge, and cells located in, or in the vicinity of, the vasculature.  Many CHS 
transgenes are "epimutable", and, for each such locus, a series of 
"epialleles" can be isolated, each eliciting a different pigmentation 
pattern.  Presumably, each epiallele is responsive to a different factor(s) 
varying spatially in the corolla.  The immediate goals of the project are: 
(1) to identify characteristics of the transgene (promoter features, 
especially) that determine responsiveness to morphological information and 
(2) to identify nuclear factors mediating this response.  Understanding 
behind the mechanism the suppression of the endogenous CHS gene by the 
transgene is (most likely) a longer term goal, best addressed once we 
understand those aspects of transgene expression necessary for 
co-suppression.  

Candidates should be experienced in standard molecular genetics technology
and have a basic understanding of genetics and plant development.  

For a review of background information:  Jorgensen, Phil. Trans. Roy. Soc. 
Lond. B (1993) 339:173-181.  Feel free to call or write.

Position funded by Japanese Ministry of Agriculture thru 3/15/96 at UC Davis.

Rich Jorgensen
Dept of Environmental Horticulture
UC Davis, Davis, Calif. 95616-8587
916-752-5807 (phone)
916-752-1819 (fax)
rajorgensen at ucdavis.edu  or
fzrjorge at bullwinkle.ucdavis.edu



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