Postdoctoral position in Medical Mycology
Dr. Yeyan Zhang
yzhang at biomed.med.yale.edu
Fri Feb 27 15:34:16 EST 1998
A postdoctoral position is available to study mechanisms by which
pathogenic fungi (eg, Candida albicans and Cryptococcus neoformans)
regulate intracellular acyclic polyols concentrations. Acyclic polyols
such as D-arabinitol and mannitol function in fungi as intracellular
osmolytes and as oxidative stress protectants, and mutants with
diminished abilities to synthesize and accumulate acyclic polyols are
stress-intolerant and hypovirulent (Microbiol 1996;142:937; J
Immunol 1996;156:3836; J Bacteriol 1997;179:157).
Our past studies have focused on the metabolic pathways by which
C. albicans and C. neoformans synthesize and catabolize polyols and the
functional and pathogenic significance of these pathways (J Bacteriol
1993;175:6314 and 1995;177:2971). The new postdoctoral associate will
study the mechanisms by which pathogenic fungi maintain and regulate
high acyclic polyol concentration gradients across the cell membrane.
One possible approach will be (i) to clone the cDNAs and/or genes
encoding the C. albicans and/or C. neoformans homologs of the yeast
and E. coli transmembrane glycerol facilitators and (ii) to use molecular
approaches to assess the functional and pathogenic significance of
these polyol transporters or facilitators.
Familiarity with basic molecular biology methods is essential.
Previous experience with yeast or other fungi and/or biochemical
and/or molecular analyses of membrane transporters is desirable.
Please send CV and the names of 3 references to Dr. Brian Wong,
Department of Internal Medicine, Yale University School of Medicine,
VA Medical Center, 950 Campbell Ave (111-I), West Haven, CT 06516
(Fax 203-937-3476; email brian.wong at yale.edu).
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