From nojunk from knology.net Thu Nov 5 16:17:50 2009 From: nojunk from knology.net (amdx) Date: Thu Nov 5 17:54:06 2009 Subject: [Cell-biology] Looking for Cell with unique Composition Message-ID: High School project, looking for something different. Do you know of any cells that I can research to make my project different than the usual. Need to make a 3D model. The Mav From bks from panix.com Thu Nov 5 16:36:30 2009 From: bks from panix.com (Bradley K. Sherman) Date: Thu Nov 5 17:54:11 2009 Subject: [Cell-biology] Re: Looking for Cell with unique Composition References: Message-ID: In article , amdx wrote: >High School project, looking for something different. >Do you know of any cells that I can research to make >my project different than the usual. >Need to make a 3D model. > The Mav > > Surprisingly, each cell that exists, and has ever existed, has unique composition. Check out these cells: --bks From nojunk from knology.net Thu Nov 5 18:48:30 2009 From: nojunk from knology.net (amdx) Date: Thu Nov 5 19:26:47 2009 Subject: [Cell-biology] Re: Looking for Cell with unique Composition References: Message-ID: "Bradley K. Sherman" wrote in message news:hcvggu$s8i$1@reader1.panix.com... > In article , > amdx wrote: >>High School project, looking for something different. >>Do you know of any cells that I can research to make >>my project different than the usual. >>Need to make a 3D model. >> The Mav >> >> > > Surprisingly, each cell that exists, and has ever existed, has > unique composition. > > Check out these cells: > > > --bks > Thanks Bradley, That's neat, looks so much like an insect walking on that bubble. Just so I'm clear, that is a single cell and the cilia are part of that cell. Many more on the site that I'll check out too. Thanks, The Mav From bks from panix.com Thu Nov 5 19:27:00 2009 From: bks from panix.com (Bradley K. Sherman) Date: Thu Nov 5 19:58:12 2009 Subject: [Cell-biology] Re: Looking for Cell with unique Composition References: Message-ID: In article , amdx wrote: >Just so I'm clear, that is a single cell and the cilia are part of that >cell. > Now, now, don't presume on my good nature. --bks From jbdundas from gmail.com Thu Nov 12 05:16:33 2009 From: jbdundas from gmail.com (jitesh dundas) Date: Thu Nov 12 12:58:51 2009 Subject: [Cell-biology] Request For Help in my project Message-ID: <326ea8620911120216y537cb1d6q768f7ee8aae1c773@mail.gmail.com> Dear Sir/Madam, I would like to invite you to become my co-author for the following paper. I need someone with lab facilities to carry out the experiments needed for this project. I need an expert like you help me get positive results in the project (details below):- Abstract:- -------------- The human cells are known to be very dynamic and continuously changing with time. They also adapt and change due to the evolution and other external/internal factors. Each cell has the capability to resist external pathogens and other objects that may be unfavorable for it. Thus, there are mechanisms in place for doing this:- Cells have numerous defenses against invading pathogens, including production of interferon, presentation on MHCI/II, and degradation of incoming RNAs by dsRNA-dependent protein kinase R (PKR). I am working on a formula that can predict the resistance of a cell toward such pathogens in future (e.g. 45 days ,365 days , etc). Suppose a cell has 70% capacity to resist a pathogen right now. What will be the capacity of the cell to resist this pathogen after 365 days. There are 2 things here to note. Firstly, we need to find the capacity of the cell to resist at this point (Some experts might call this immunity, but I am being specific to a specific disease i.e. Cancer/HIV Aids here). We cannot consider this formula to be measuring just the amount of interferon ,p53 or other cancer related parameters as they alone do not lead to cancer. Secondly, we need to find the future capability of this cell to resist such pathogens. There are several parameters in play here. Also, we need to understand these things:- a) The cells are continuously changing due to evolution and have a life till apoptosis. b) The pathogens or external agents are also dynamic and evolving with time .For diseases TB and Swine flu, the virus is changing its shape every 6 months c) The pathogens may combine and form a very strong hybrid strand of pathogens, against which our cells may be weak. For e.g.) It is elementary that the current swine flu will form a deadly strand with HIV AIDS virus and become very deadly. d) Both these complex systems are evolving with time and with the life cycle and reproduction capabilities, we need to find the exact capabilities of each of the above conditions. What I want in a formula is the capacity (consider the unit for this measure as immunity units/day) which will allow me to make a probabilistically accurate measure of the resistance of the cell against an invading pathogen in future. For now, we consider known pathogens, but I intend to extend this to unknown strands as well. References:- ---------------------- Lodish et al, Introduction to Cell & Molecular Biology Takaoka A, Hayakawa S, Yanai H, et al. (2003). "Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence". Nature 424 (6948): 516=9623. doi:10.1038/nature01850. PMID 12872134. http://www.nature.com/nature/journal/v424/n6948/pdf/nature01850.pdf. http://www.cehs.siu.edu/fix/medmicro/mhc.htm Weiss RA. How does HIV cause AIDS? Science. 1993 May 8;260(5112):1273-9.URL: http://www.ncbi.nlm.nih.gov/pubmed/8493571 D J Alexander. Ecological aspects of influenza A viruses in animals and their relationship to human influenza: a review. J R Soc Med. 1982 October; 75(10): 799=96811.Online: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=3D1438138&blobtype=3D= pdf ---------------------- May I request your feedback on the above topic. I have developed the initial version of this formula which I expect to present in 1-2 months. Still, think it will be best to take the opinion of experts like you on this topic. I look forward to hearing from you soon. I understand that you are very busy and I thank you for reading this message. Please let me know if you need anything else from my side. I eagerly await your reply Thanks & Regards, Jitesh Dundas jitesh@bioclues.org