From jprudhomme from healthtech.com Thu Oct 1 14:08:11 2009 From: jprudhomme from healthtech.com (Jim Prudhomme) Date: Thu Oct 1 20:16:45 2009 Subject: [Computational-biology] Adopting R&D Informatics Systems Message-ID: <00dc01ca42ca$851a49c0$8f4edd40$@com> Part of the Diagnostics Channel at CHI's 17th International Molecular Medicine Tri-Conference. Cambridge Healthtech Institute's Second Annual Adopting R&D Informatics Systems: Data Management, Integration & Knowledge Management February 3-5, 2010 Moscone North Convention Center * San Francisco, CA Register by October 9 and Save up to $350: http://www.tri-conference.com/ird.asp Speaker Presentations: Enterprise Scientific Workflow Environment Drives Innovation Juergen Hammer, Ph.D., M.B.A., Pharma Research Scientific Informatics; Global Head, In Silico Sciences; Center Head, Scientific Informatics, F. Hoffmann-La Roche, Inc. The Pistoia Alliance, Inc.-A Construct for Precompetitive Collaboration Chris Waller, Ph.D., Senior Director, Precompetitive Collaborations, Research, Development & Medical Informatics, Worldwide Technology, Pfizer, Inc. Recent Strategies with Cloud, Wikis, Ontologies and Open Source Data Standards Giles M. Day, Senior Director, BBC Informatics, Pfizer, Inc. Luncheon Presentation Sponsored by Microsoft Personalized Medicine: The Missing Pieces Jim Karkanias, Senior Director of Applied Research & Technology, Microsoft Health Solutions Group Integrated Informatics Systems for R&D John Reynders, Ph.D., CIO, Pharmaceutical Research & Development, Johnson & Johnson Executive Panel with Q&A Are We Integrating the Right Data: Extending Beyond Laboratory Data to Decisions Impacting Project Success Moderator: David M. Sedlock, Ph.D., Senior Director, Research & Development Systems, Millennium, The Takeda Oncology Company Presentation Sponsored by Accelrys Knowledge Management David Hodgson, Ph.D., Site Head, Global Research Informatics, Roche Palo Alto Knowledge for Strategic Advantage: Accelerating the R&D Cycle Thomas P. Hill, Principal, The Leverage Innovation Group; former Director, Learning and Knowledge Management, Genentech ASAP-Emphasizing Multidimensional Drug Discovery W. Patrick Walters, Ph.D., Senior Research Fellow & Group Head, Computational Drug Discovery Technologies, Vertex Pharmaceuticals, Inc. Agile Software Development: Meeting the Rapidly Changing Needs in Drug Discovery Man-Ling Lee, Ph.D., Senior Program Analyst, Discovery Chemistry, Small Molecule Drug Discovery, Genentech, Inc. Application of Translational Informatics in Tailored Therapeutics Susie Stephens, Director, Biomedical Informatics, Pharmaceutical Research & Development, Johnson & Johnson Data Integration-What's in it for Me? Randal Chen, Ph.D., Director, Research Informatics, Amgen, South San Francisco Integrative Data Mining for Drug Discovery using the Semantic Web Michael Lajiness, Ph.D., Research Scientist, Structural and Computational Sciences, Eli Lilly & Company Collaborative Drug Discovery Humanitarian and Commercial Researcher Network Case Studies Barry A. Bunin, Ph.D., Chief Executive Officer & President, Collaborative Drug Discovery (CDD), Inc. Panel: Drug Discovery Collaborations in 2010 Moderator: Barry A. Bunin, Ph.D., Chief Executive Officer & President, Collaborative Drug Discovery (CDD), Inc. Implementing a Translational Biomarker Strategy to Reduce Attrition in Drug Development Irina Antonijevic, M.D., Ph.D., Director, Translational Research, Biological Research, Lundbeck Research, Inc. USA High Content Mining of Disease Biomarkers Jake Chen, Ph.D., Assistant Professor, Informatics & Computer Science, Indiana University School of Informatics; Director, Indiana Center for Systems Biology and Personalized Medicine, Indiana University-Purdue University Indianapolis; Founder, MedeoLinx, Inc. Profiling Patients to Drive Biomarker Development N. R. Nirmala, Ph.D., Director, Biomarker Analysis and Informatics Unit, Translational Sciences, Novartis Institutes of Biomedical Research Panel: Informatics at R&D Interphases Moderator: Pearl S. Huang, Ph.D., Integrator, Oncology Franchise, Research & Early Development, Merck & Co. Image Analysis Considerations for Pre-clinical, in vivo Medical Imaging Matt Silva, Head, Imaging Sciences, Millennium, The Takeda Oncology Company RISe Prowler: A Semantic Web Approach to Integrating External and In-house Biology and Chemistry Information Ajay Shah, Ph.D., MBA, PMP, Director, Research Informatics, Elan Pharmaceuticals, Inc. Development of a Registration System for Biologics in a Collaborative Special Interest Group Jeremy Packer, Ph.D., Head, Bioinformatics, Abbott Semantic Web and Cloud Computing for Integrative Data Management and Analysis Infrastructure Jonas S. Almeida, Ph.D., Abell-Hanger Distinguished Professor, Bioinformatics and Computational Biology, University of Texas, M.D. Anderson Cancer Center How to Register: Telephone: 781-972-5400 Fax: 781-972-5425 Email: reg@healthtech.com To inquire about sponsorship and exhibit options, contact: Carol Dinerstein, 781-972-5471, dinerstein@healthtech.com or Jon Stroup, 781-972-5483, jstroup@healthtech.com Posted by: James Prudhomme Marketing Manager Cambridge Healthtech Institute 250 First Avenue, Suite 300 Needham, MA 02494 Direct: 781-972-5486 Fax: 781-972-5425 www.healthtech.com From conf from topaz.gatech.edu Thu Oct 8 19:27:18 2009 From: conf from topaz.gatech.edu (Georgia Tech Conference Announcement) Date: Thu Oct 8 21:25:55 2009 Subject: [Computational-biology] 7th Georgia Tech - ORNL Conference on Bioinformatics Message-ID: <20091009002722.33237231238@topaz.gatech.edu> Call for Paper Abstracts is extened --------------------------------- Dear Colleagues The 7th Georgia Tech - ORNL Conference on Bioinformatics - In silico Biology: Genome Biology and Bioinformatics will be held in Atlanta, Georgia, November 12-14, 2009 http://www2.isye.gatech.edu/binf2009/ Georgia Tech continues the tradition of organizing biennial International Conference on Bioinformatics, bringing together leading researchers in genomics, bioinformatics and genome biology to present recent advances in the field and to discuss open problems. Important Dates Deadline for poster abstract subsmission: October 11, 2009 Notification of acceptance of abstracts: October 20, 2009 Deadline for early registration: October 23, 2009 We invite papers submissions in the following areas * genomics * transcriptomics * proteomics * reconstruction and modeling of gene networks * evolutionary biology SPEAKERS Margaret O. Dayhoff lecture: David Lipman, NCBI/NIH, Bethesda, MD, USA Plenary Speakers: Vineet Bafna, University of California at San Diego, USA Gill Bejerano, Stanford University, Stanford, CA, USA Jeffrey Bennetzen, University of Georgia, Athens, GA, USA Mark Borodovsky, Georgia Tech and Emory University, Atlanta, GA, USA Nick Grishin, University of Texas, Dallas, TX, USA Curtis Huttenhower, Harvard University, Boston, MA, USA King Jordan, Georgia Tech, Atlanta, GA, USA Igor Jouline (Zhulin), University of Tennessee - ORNL, Oak Ridge, TN, USA Eugene Koonin, NCBI/NIH, Bethesda, MD, USA Nikos Kyrpides, DOE Joint Genome Institute, Walnut Creek, CA, USA Boris Lenhard, University of Bergen, Norway Jian Ma, University of Illinois at Urbana Champaign, Urbana, IL, USA Yael Mandel-Gutfreund, Technion, Israel Insitute of Technology, Haifa, Israel Joanna Masel, University of Arizona, Tucson, AZ, USA Andrey Mironov, Moscow State University, Russia Andrei Osterman, Burnham Institute for Medical Research, La Jolla, CA USA Karen Nelson, J. Craig Venter Institute, Rockville, MD, USA Natasa Przulj, Imperial College London, UK John Reinitz, State Uiversity of New York at Stony Brook, NY, USA Pierre Rouze, Gent University, Gent, Belgium CONFERENCE CHAIRS Mark Borodovsky, Georgia Tech and Emory University Eva K. Lee, Georgia Tech and Emory University PROGRAM COMMITTEE Nicholas Bergman, Georgia Tech Dmitrij Frishman, Technische Universitaet Muenchen, Germany Andrey Gorin, Oak Ridge National Laboratory Andrzej M. Kierzek, University of Surrey, UK. Eileen Kraemer, University of Georgia Jun Liu, Harvard University Hannah Margalit, Hebrew University Andrey Rzhetsky, University of Chicago Andre Rogatko, Samuel Oschin Comprehensive Cancer Institute Gary Stormo, Washington University Lance Waller, Emory University Ying Xu, University of Georgia and Oak Ridge National Laboratory Soojin Yi, Georgia Tech Igor Zhulin, Oak Ridge National Laboratory and University of Tennessee ADMINISTRATION Harry Sharp, Georgia Tech CONFERENCE LOCATION The Georgia Tech Ferst Center for the Arts. From mourad12345678 from yahoo.com Wed Oct 14 22:14:55 2009 From: mourad12345678 from yahoo.com (Mourad Elloumi) Date: Thu Oct 15 09:47:38 2009 Subject: [Computational-biology] ACS/IEEE'10 (Hammamet, Tunisia May 16-19, 2010) - Extended Deadline Message-ID: <221671.47903.qm@web31502.mail.mud.yahoo.com> Dear all, The deadline for the submission of abstracts to AICCSA'10 has been extended to October 27, 2009. Best regards, Mourad Elloumi. ______________________________________________________ ? Mobile :+216 98 46 88 59 E.Mail:Mourad.Elloumi@fsegt.rnu.tn URL?? :www.esstt.rnu.tn/utic/english/memb_elloumi.html ______________________________________________________ From events from embl-events.de Wed Oct 21 08:22:36 2009 From: events from embl-events.de (EMBL Courses & Conferences) Date: Wed Oct 21 08:33:02 2009 Subject: [Computational-biology] Visualizing Biological Data, 3-5 March 2010: Deadline on 16 Nov 2009 Message-ID: <0M1iEk-1M7FRK00BW-00tfJE@mrelayeu.kundenserver.de> Dear colleagues, We invite you to participate in the first EMBO Workshop on Visualizing Biological Data (VizBi, http://www.vizbi.org) 3 - 5 March 2010 at the EMBL's new Advanced Training Centre in Heidelberg, Germany The goal of the workshop is to bring together, for the first time, researchers developing and using visualization systems across all areas of biology, including genomics, sequence analysis, macromolecular structures, systems biology, and imaging (including microscopy and magnetic resonance imaging). We have assembled an authoritative list of 29 invited speakers who will present an exciting program, reviewing the state-of-the-art and perspectives in each of these areas. The primary focus will be on visualizing processed and annotated data in their biological context, rather than on processing of raw data. The workshop is limited in the total number participants, and each participant is normally required to present a poster and to give a 'fastforward' presentation about their work (limited to 30 seconds and 1 slide). To apply to join the workshop, please go to http://vizbi.org and submit an abstract and image related to your work. Submissions close on 16 November 2009. Since places are limited, participants will be selected based on the relevance of their work to the goals of the workshop. Notifications of acceptance will be sent within three weeks after the close of submissions. We plan to award a prize for the submitted image that best conveys a strong scientific message in a visually compelling manner. Please forward this announcement to anyone who may be interested. We hope to see you in Heidelberg next spring! Seán O'Donoghue, EMBL Jim Procter, University of Dundee Nils Gehlenborg, European Bioinformatics Institute Reinhard Schneider, EMBL If you have any questions about the registration process please contact: Adela Valceanu Conference Officer European Molecular Biology Laboratory Meyerhofstr. 1 D-69117 Heidelberg Tel: +49-6221-387 8625 Fax: +49-6221-387 8158 Email: valceanu@embl.de For full event listings please visit our website: www.embl.org/events or sign up for our newsletter www.embl.de/events/newsletter From mcdevitt from ibb.gatech.edu Thu Oct 22 11:31:23 2009 From: mcdevitt from ibb.gatech.edu (Megan McDevitt) Date: Thu Oct 22 13:50:06 2009 Subject: [Computational-biology] International Conference - Genome Biology and Bioinformatics Message-ID: Dear Colleagues, The 7th Georgia Tech - ORNL Conference - "Genome Biology and Bioinformatics" to be held on November 12-14, 2009 is now less than a month away: http://www2.isye.gatech.edu/binf2009/ The program of the conference features talks of many leading experts in the field http://www2.isye.gatech.edu/binf2009/speakers_2009.php Thanks to financial support from a larger group of sponsors we are happy to announce that the registration fee is reduced to: $20 student/postdoc $50 - academic $100 - industry Deadline for poster abstract submission is extended to November 1 We hope to see you soon in the Georgia Tech Ferst Center for the Arts _____________________________________ Invited Speakers Margaret O. Dayhoff Lecture David Lipman, NCBI/NIH, Bethesda, MD, USA Margaret Dayhoff and Molecular Evolution in the 21st Century Vineet Bafna, University of California at San Diego, USA Proteogenomics Gill Bejerano, Stanford University, Stanford, CA, USA Genomics and the Evolution of Human-Specific Traits Jeffrey Bennetzen, University of Georgia, Athens, GA, USA The Hyperevolution of Artifacts and Realities in the Structure and Function of Higher Plant Genomes Mark Borodovsky, Georgia Tech and Emory University, Atlanta, GA, USA Gene Finding in the Era of Next Generation Sequencing Nick Grishin, Howard Hughes Medical Institute, University of Texas, Dallas, TX, USA Evolutionary Classification of Protein Structures Curtis Huttenhower, Harvard University, Boston, MA, USA Large Scale Genomic Data Mining King Jordan, Georgia Tech, Atlanta, GA, USA MIR Elements Provide Chromatin Boundaries to the Human Genome Igor Jouline, University of Tennessee - Oak Ridge National Laboratory, Oak Ridge, TN, USA Molecular Evolution of a Complex Signal Transduction System in Prokaryotes Eugene Koonin, NCBI/NIH, Bethesda, MD, USA Systems Biology and the Prospects of a Post-Modern Evolutionary Synthesis Nikos Kyrpides, DOE Joint Genome Institute, Walnut Creek, CA, USA The Future of Microbial Genomics Boris Lenhard, University of Bergen, Norway Long-, Short- and Mid-Range Gene Regulation: Lessons from Genome-Wide Patterns of Sequence Conservation and Transcription Factor Binding Jian Ma, University of Illinois at Urbana Champaign, Urbana, IL, USA Unraveling the Ancestral Mammalian Genome Yields Insights into the Human Genome Yael Mandel-Gutfreund, Technion, Israel Institute of Technology, Haifa, Israel Deciphering the Role of Alternative Splicing in Modulating the Human Gene Regulatory Network Joanna Masel, University of Arizona, Tucson, AZ, USA The Origin of New Coding Sequences Andrey Mironov, Moscow State University, Russia Conserved Intronic RNA Secondary Structures Karen Nelson, J. Craig Venter Institute, Rockville, MD, USA Studies of The Human Microbiome Andrei Osterman, Burnham Institute for Medical Research, La Jolla, CA USA Integrated Genomic Reconstruction of Metabolic and Regulatory Networks in Bacteria Natasa Przulj, Imperial College London, UK >From Network Topology to Biological Function and Disease John Reinitz, State University of New York at Stony Brook, NY, USA When Two Plus Two Doesn't Equal Four: Modeling Non-Modular Enhancer Behavior in the Eve Promoter Pierre Rouze, Gent University, Gent, Belgium >From Protists to Plants, Fungi and Animals: Eukaryote Genomes Are Not Born Equal This email was sent to comp-bio@net.bio.net= From prash from bioclues.org Fri Oct 23 02:23:25 2009 From: prash from bioclues.org (Prash) Date: Fri Oct 23 11:13:28 2009 Subject: [Computational-biology] Cfp: The first Indian virtual conference on Bioinformatics (Inbix '10) Message-ID: <737475c3-2cfe-46a7-b857-1a6e4719a332@x5g2000prf.googlegroups.com> Dear All, This is the first call and announce for Indian virtual conference on Bioinformatics (Inbix '10) For more details, please visit http://www.bioinformatics.org/wiki/Inbix10. There are various speakers of repute in the area of Systems Biology and Bioinformatics. Registration starts October 15, 2009. Stay tuned for more announcements. If you are a group of 15 or more, you can form a virtual hub. This is organized by Bioclues.org and Bioinformatics.org. for further information and news, please contact the organizers. Sincerely Prash for Inbix'10 organizers Prashanth Suravajhala C-DAC-Bioinformatics Group, Pune, India http://wiki.bioinformatics.org/prash “If you only have a hammer, you tend to see every problem as a nail." ~Abraham Maslow From andrea.splendiani from bbsrc.ac.uk Fri Oct 30 00:55:10 2009 From: andrea.splendiani from bbsrc.ac.uk (Andrea Splendiani) Date: Fri Oct 30 11:22:37 2009 Subject: [Computational-biology] Title: SWAT4LS Call for participation Message-ID: *** apologies for multiple postings *** Registration is now open for SWAT4LS Semantic Web Applications and Tools for Life Sciences to be held in Amsterdam, Science Park, 20th November 2009 Registration: http://www.swat4ls.org/2009/rform.php#rform ------------------------------ Provisional scientific program: Keynotes: * Alan Ruttenberg: Semantic Web Technology to Support Studying the Relation of HLA Structure Variation to Disease * Barend Mons: (provisional) CWA: The meta-analysed Semantic Web , getting rid of ambiguity and redundancy * Michael Schroeder: Prediction of drug-target interactions from literature by context similarity Accepted papers: * OBO & OWL: Roundtrip Ontology Transformations Syed Hamid Tirmizi, Stuart Aitken, Dilvan Moreira, Chris Mungall, Juan Sequeda, Nigam H. Shah and Daniel P. Miranker. * Mining Semantic Networks of Bioinformatics e-Resources from Literature Hammad Afzal, James Eales, Robert Stevens and Goran Nenadic. * Linking Open Drug Data to Cheminformatics and Proteochemometrics Egon Willighagen and Jarl Wikberg. * TIM: A Semantic Web Application for the Specification of Metadata Items in Clinical Research Matthias L?be, Magnus Knuth and Roland M?cke. * Semantics-Based Composition of EMBOSS Services with Bio-jETI Anna-Lena Lamprecht, Stefan Naujokat, Tiziana Margaria and Bernhard Steffen. * Towards the Ontology-based Classification of Lymphoma Patients using Semantic Image Annotations Sonja Zillner. Short communications: * Weekend Triple Billionaire Jerven Bolleman and Thomas Kappler. * Towards a Logic-based Assessment of the compatibility of UMLS sources Ernesto Jimenez-Ruiz, Bernardo Cuenca Grau, Rafael Berlanga and Ian Horrocks. * Using the NCBO Web Services for Concept Recognition and Ontology Annotation of Expression Datasets Simon Twigger, Joey Geiger and Jennifer Smith. Demos: * A system for repairing missing is-a structure in ontologies Patrick Lambrix, Qiang Liu and He Tan. * NeuroLex.org - A semantic wiki for neuroinformatics based on the NIF Standard Ontology Stephen Larson, Sarah Maynard, Fahim Imam and Maryann Martone. * ContentCVS: A CVS-based Collaborative ONTology ENgineering Tool Ernesto Jimenez-Ruiz, Bernardo Cuenca Grau, Ian Horrocks and Rafael Berlanga. * DC-THERA Directory, a Knowledge Management System for the support of the European Dendritic Cell Immunology Community Marco Brandizi, Michaela G?ndel, Ciro Scognamiglio and Andrea Splendiani. Panel discussion: Theme: TBD Plus poster sessions (authors of posters are not listed in this call, but will be listed on the website) An updates version of the program will be available at http://www.swat4ls.org/2009/progr.php Early registrations are very appreciated. ---------------------------------------- Registrations costs: full registration: 50 euros social dinner (optional): 35 euros PhD students: free (subject to availability) To register please visit: http://www.swat4ls.org/2009/rform.php#rform Organization * M. Scott Marshall, Leiden University Medical Center / University of Amsterdam, The Netherlands * Albert Burger, School of Mathematical and Computer Sciences, Heriot-Watt University, and Human Genetics Unit, Medical Research Council, Edinburgh, Scotland, United Kingdom * Adrian Paschke, Corporate Semantic Web, Freie Universitaet Berlin, Germany * Paolo Romano, Bioinformatics, National Cancer Research Institute, Genova, Italy * Andrea Splendiani, Biomathematics and Bioinformatics dept., Rothamsted Research, UK More information * http://www.swat4ls.org/2009/ * http://swat4ls.blogspot.com * info@swat4ls.org ------------ We wish to thank once again the review panel that made this possible: * Christopher J. O. Baker, Department of Computer Science and Applied Statistics, University of Brunswick, Canada * Pedro Barahona, Department of Informatics, New University of Lisboa, Lisboa, Portugal * Liliana Barrio-Alvers, Transinsight GmbH, Dresden, Germany * Olivier Bodenreider, National Library of Medicine, Bethesda, MD, United States of America * Matt-Mouley Bouamrane, School of Computer Science, University of Machester, manchester, United Kingdom * Werner Ceusters, NY CoE in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, NY, United States of America * Kei Cheung, Center for Medical Informatics, Yale University School of Medicine, New Haven, United States of America * Tim Clark, Massachusetts General Hospital and Harvard Medical School, Boston MA, United States of America * Marie-Dominique Devignes, LORIA, Vandoeuvre les Nancy, France * Olivier Dameron, INSERM U936, University of Rennes 1, France * Michel Dumontier, Carleton University, Ottawa, Ontario, Canada * Huajun Chen, Zhejiang University, China * Duncan Hull, School of Chemistry, University of Manchester, UK * C. Maria Keet, Faculty of Computer Science, Free University of Bozen-Bolzano, Bolzano, Italy * Graham Kemp, Chalmers University of Technology, Sweden * Jacob Tilman Koehler, Department of Molecular Biotechnology, Institute of Medical Biology, University of Troms?, Troms?, Norway * Michael Krauthammer, Department of Pathology, Yale University School of Medicine, United States of America * Martin Kuiper, Department of Pathology, Systems Biology group, Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway * Patrick Lambrix, Department of Computer and Information Science, Link?ping University, Link?ping, Sweden * Phillip Lord, School of Computing Science, Newcastle University, Newcastle-upon-Tyne, United Kingdom * M. Scott Marshall, Leiden University Medical Center / University of Amsterdam, The Netherlands * Chris Mungall, Lawrence Berkeley National Laboratories, United States of America * Stephan Philippi, Institute for Software Technology, University of Koblenz-Landau, Koblenz, Germany * Marco Roos, Instituut voor Informatica, University of Amsterdam, Netherlands * Alan Ruttenberg, Science Commons, Cambridge, MA, United States of America * Matthias Samwald, DERI, Galway, Ireland, and Konrad Lorenz Institute for Evolution and Cognition Research, Altenberg, Austria * Nigam Shah, Center for Biomedical Informatics Research, Stanford, United States of America * Michael Schr?der, Biotechnology Centre, TU Dresden, Dresden, Germany * Robert Stevens, School of Computer Science, University of Manchester, Manchester, United Kingdom * Tetsuro Toyoda, Genomic Sciences Center, RIKEN, Yokohama, Japan * Mark D. Wilkinson, iCAPTURE Center, St. Paul Hospital, Vancouver, Canada From niels.kruize from kbioscience.co.uk Fri Oct 30 10:49:53 2009 From: niels.kruize from kbioscience.co.uk (Niels Kruize / KBiosciences) Date: Fri Oct 30 11:28:49 2009 Subject: [Computational-biology] DNA Fragmentation: The Critical First Step in Next Generation Sequencing Message-ID: <20091030.XCCOOALVXWEQYZOR@kbioscience.co.uk> Topic:Controlled DNA Fragmentation: The Critical First Step in Next Generation Sequencing When: November 11, 2009 Time: 11:00a.m. EST Duration: Presentation: 30 Minutes Discussion: 30 Minutes Hosts: Introduction: Jim Laugharn, Founder and CEO Presentation: Hamid Khoja, Ph.D., Senior Applications Scientist Registration: To register for the online event: 1. Click here 2. Click Register 3. On the registration form, enter your information and then click Submit. You will receive a confirmation email and an event reminder. What You Will Learn: The important role of Controlled DNA Fragmentation in the sample preparation process for Next Generation Sequencing. What DNA Fragmentation methods are commercially available today for Fragment and Mate-Pair Libraries. How the Covaris AFA process works. Additional key applications and services. Webinar Abstract: DNA fragmentation is the most critical sample preparation step required by all the currently available next generation sequencing platforms. The sensitivity and broader application depth of these platforms necessitates the utilization of an efficient, easy to use, high throughput capable, and highly reproducible DNA fragmentation technology. Although nebulization, enzymatic digestion, hydrodynamic shearing, and sonication have been used to shear DNA, they all have significant disadvantages, which cause them to be a weak point in the workflow for next generation sequencing technologies. Drawbacks include thermal and sequence specific biased shearing, thermal degradation, sample loss, automation difficulties, and user-based issues. The Covaris AFA process stands out as the preferred method for easily and reproducibly fragmenting DNA ranging from 100bp to 5kb in length. In this meeting we will provide details of the Covaris AFA technology, and the distinct advantages it provides when compared to other DNA shearing methodologies. We will also present data to showcase the control and reproducibility of our validated protocols when fragmenting DNA in the 100bp to 5kb size range. Also discussed will be the use of AFA technology in chromatin fragmentation for ChIP-chip, ChIP-seq, and RNA fragmentation applications. About Covaris At Covaris, we believe that high value samples deserve controlled preparation, prior to committing to high cost analysis. Covaris' line of high-performance focused ultra-sonicators deliver industry-leading sample processing capability directly to the benchtop. We provide workstation-based instruments capable of extremely rapid and complete DNA/RNA/Chromatin fragmentation, tissue disruption, and non-contact isothermal homogenization of cell culture, tissue, and organisms for DNA, RNA, protein, and metabolites extraction. The Covaris family of instruments provides single through 96 sample preparation with scalable acoustic energy, capable of processing a wide range of sample types and volumes. With over 850 installations, the Covaris proprietary and patented Adaptive Focused Acoustics? (AFA) technology enables numerous non-contact, isothermal sample preparation processes for use in a broad range of applications including Genomics, Proteomics, and Drug Discovery research. For more information about Covaris and AFA, please visit us at Covarisinc.com or on KBioscience. 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