From owner-emf-bio@net.bio.net Sun Jan 21 22:00:00 1996
Path: biosci!biosci!not-for-mail
From: Ben Greenebaum <greeneba@cs.uwp.edu>
Newsgroups: bionet.emf-bio
Subject: Bioelectromagnetics Vol. 16, No. 6, 1995 Table of Contents (fwd)
Date: 22 Jan 1996 05:31:25 -0800
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BIOELECTROMAGNETICS
VOLUME 16, No. 6, 1995 Table of Contents
==============================================================================
NOTE: Please contact your library or the authors for reprints or further 
information about specific articles, NOT the Editor, Society or Publisher!

For information about the journal, contact the Editor.  For member 
subscription information, contact the Society at 7519 Ridge Road, 
Frederick, MD 21702-3519.  For library or other non-member subscription 
information, contact the publisher, Wiley/Liss, Inc., 605 Third Avenue, 
New York, NY 10158-0012, Attn: Subscription Dept., 9th Floor.

Ben Greenebaum, Editor
University of Wisconsin-Parkside, Box 2000, Kenosha, WI  53141-2000
414-595-2140; Fax 414-595-2056
Internet: bems@cs.uwp.edu
==============================================================================
Bioelectromagnetics

Journal of the Bioelectromagnetics Society, the European 
Bioelectromagnetics Association and the 
Society for Physical Regulation in Biology and Medicine

Volume 16, Number 6, 1995

(c) 1995 Wiley-Liss, Inc.

Articles

343  Biologic Effects of Prolonged Exposure to ELF Electromagnetic Fields 
in Rats: II. 50 Hz Magnetic Fields
   V. Margonato, P. Nicolini, R. Conti, L. Zecca, A. Veicsteinas, and
P. Cerretelli 

356  Spectral Analysis of Magnetic Fields From Domestic Appliances and 
Corresponding Induced Current Densities in an Anatomically Based Model of 
the Human Head
   Santi Tofani, Laura Anglesio, Piero Ossola, and Giovanni d'Amore

365  Residential Exposure to Magnetic Fields Generated by 110-400 kV 
Power Lines in Finland
   Jorma Voljus, Mikko Hongisto, Pia Verkasalo, Pekka Jarvinen,
Kauko Heikkila, and Markku Koskenvuo

377  Sinusoidal 50 Hz 500 uT Magnetic Field Has No Acute Effect on 
Urinary 6-Sulphatoxymelatonin in Wistar Rats
   Jozsef Bakos, Noemi Nagy, Gyorgy Thuroczy, and Laszlo D. Szabo

381  Action of 50 Hz Magnetic Fields on Cyclic AMP and Intercellular 
Communication in Monolayers and Spheroids of Mammalian Cells
   Jutta Schimmelpfeng, Johannes-Christoph Stein, and Hermann Dertinger

387  Frequency-Dependent Interference by Magnetic Fields of Nerve Growth 
Factor-Induced Neurite Outgrowth in PC-12 Cells
   C.F. Blackman, S.G. Benane, and D.E. House

Forum Paper

396  Designing EMF Experiments: What is Required to Characterize "Exposure"?
   Peter A. Valberg

402  Comment on "Designing Experiments: What is Required to Characterize 
'Exposure'?"
   W.T. Kaune

405  Comment on "Designing Experiments: What is Required to Characterize 
'Exposure'?"
   B. Wilson

406  Reply to Comments on "Designing Experiments: What is Required to 
Characterize 'Exposure'?"
   Peter A. Valberg

Comments

407  Comment on "Absorbed Energy Distribution From Radiofrequency 
Electromagnetic Radiation in a Mammalian Cell Model: Effect of 
Membrane-Bound Water," by Liu and Cleary
   Asher R. Sheppard and Quirino Balzano

408  Reply to "Comment on 'Absorbed Energy Distribution From 
Radiofrequency Electromagnetic Radiation in a Mammalian Cell Model: 
Effect of Membrane-Bound Water,' by Liu and Cleary"
   Li-Ming Liu and Stephen F. Cleary

409  Erratum

410  Referees for Bioelectromagnetics, 1995

413  Author Index for Volume 16

415  Subject Index for Volume 16

(c) 1995 Wiley-Liss, Inc.	 



From owner-emf-bio@net.bio.net Sun Jan 21 22:00:00 1996
Path: biosci!biosci!not-for-mail
From: tvaughan@athena.mit.edu (Timothy E Vaughan)
Newsgroups: bionet.emf-bio
Subject: Gordon Research Conference [LONG]
Date: 22 Jan 1996 05:27:02 -0800
Organization: Massachusetts Institute of Technology
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Keywords: electrochemistry, electric fields, magnetic fields, EMF


GORDON RESEARCH CONFERENCES:  BIOELECTROCHEMISTRY

  Molecular and Cellular Biophysics of the Alteration of

  Biochemical Reactions and Transport by Electric and Magnetic Fields

[Complete program, with list of confirmed speakers, appears below.]


TIME AND PLACE

July 21 - 26, 1996, Salve Regina University, Newport, Rhode Island


COSTS

Conference fee (registration, board and room)

	Double occupancy	$540 per person
	Single occupancy	$590
	

TRAVEL -  Individual responsibility
	  (in some cases partial funding may be available)

FINANCIAL SUPPORT - Some funding may become available to partially
                    support participation.  This will depend on available
                    funds and individual needs.

APPLICATION PROCEDURE

	[1]  Make formal application to Gordon Research Conference to one of

		Mail delivery:

		Conference Application
		Gordon Research Conferences
		University of Rhode Island
		P.O. Box 984
		West Kingston, RI 02892-0984

		Commercial delivery (FedEx, DHL, UPS, etc.)

		Conference Application
		Gordon Research Center
		3071 Route 138,
		Kingston, RI 02881 USA


	[2]  Send written copy by mail to

		James C. Weaver
		20A-128, MIT
		Cambridge, MA 02139

	     or by email to

		grc_copy@geldrop.mit.edu

	     Sending us a copy of your application is important, because
	     in the past some applications apparently were misdirected,
	     and then lost.  If we do not know early that you applied, it
	     may be too late to help by the time we learn of a problem.

POSTERS - Participants are encouraged to present recent and ongoing work;
          a number of these will be selected for brief oral presentation
          and discussion (see PROGRAM)

UPDATE - For the latest information send email to

         grc_up@geldrop.mit.edu


PROGRAM

Molecular and Cellular Biophysics of the Alteration of

Biochemical Reactions and Transport by Electric and Magnetic Fields


James C. Weaver, Chair; Paul Gailey, Vice Chair


July 21	Sunday (arrival)	18:00 Dinner/reception

July 22	Monday Morning

BIOPHYSICAL MECHANISMS OF MAGNETIC FIELD RECEPTION I.

Imre Gyuk (Discussion Leader)

08:45	Opening/Instructions

09:00 - 10:00	PETER VALBERG  Magnetic particles in cells and tissues:

		characteristics and their interactions with magnetic fields

10:00 - 10:30	Coffee break

10:30 - 11:00	ATSUKO KOBAYASHI  Biogenic magnetite and ferromagnetic

		contaminantion in biological materials


11:00 - 11:30	JOE KIRSCHVINK  Ferromagnetism as a mechanism for electromagnetic

		field effects

11:30 - 12:30	KLAUS SCHULTEN  Recent developments in the understanding of

		magnetically sensitive radical-pair reactions


12:30	Lunch

17:00 - 18:00	Social/Poster I

18:00	Dinner


	Monday Evening

BIOPHYSICAL MECHANISMS OF MAGNETIC FIELD RECEPTION II.

Mike Marron (Discussion Leader)

19:30 - 20:30	CHUCK GRISSOM  Radical pair interactions as the possible basis

		for effects due to small fields

20:30 - 21:00	ROBERT ADAIR  Limitations on radical pair interactions for weak

		magnetic fields

21:00 - 21:30	TIMOTHY VAUGHAN  Alteration of rates via magnetic particles

		and radical pair processes

July 23	Tuesday Morning


BIOPHYSICAL MECHANISMS OF MAGNETIC FIELD RECEPTION III.


Chuck Rafferty (Discussion Leader)

09:00 - 10:00	JAN WALLECZEK  Electromagnetic field effects on cell

		calcium signaling and free radical mechanisms

10:00 - 10:30	Coffee break

BIOPHYSICAL MECHANISMS OF ELECTRIC FIELD RECEPTION I.

10:30 - 11:30	AD KALMIJN  The response of ampullae of Lorenzini

		to small dc and ac fields


11:30 - 12:30	KEN MCLEOD  Response of bone-related cells to small

		electric fields in vitro and in vivo

12:30	Lunch

17:00 - 18:00	Social/Poster II

18:00	Dinner


	Tuesday Evening

MOLECULAR AND BIOPHYSICAL EVENTS IN MEMBRANE PROTEINS I.


Charles Bean (Discussion Leader)


19:30 - 20:30	FERNAN JARAMILLO  The performance of biological sensory

		systems:  experimental behavior compared to theoretical limits

20:30 - 21:30	DEAN ASTUMIAN  Biophysical mechanisms:  fundamental constraints

		on interactions involving voltage-deformed membrane proteins

July 24	Wednesday Morning

MOLECULAR AND BIOPHYSICAL EVENTS IN MEMBRANE PROTEINS II.


Felix Hong (Discussion Leader)


09:00 - 10:00	RICHARD ALDRICH  Molecular biology and biophysics of voltage-gated

		potassium channels

10:00 - 10:30	Coffee break

10:30 - 11:30	LOUIS DEFELICE  Voltage-dependent neurotransmitter transporters

		

11:30 - 12:30	GARY YELLEN  Molecular biophysics of voltage-gated potassium

		channels

12:30	Lunch

17:00 - 18:00	Social/Poster III

18:00	Dinner


	Wednesday Evening

ELECTRICALLY DRIVEN TRANSPORT ACROSS BIOLOGICAL BARRIERS I.

K. Kinosita (Discussion Leader)

19:30 - 20:30	PHILIP GREEN  Transdermal drug delivery of peptides and

		small molecules by iontophoresis

20:30 - 21:30	JANET TAMADA  Electrically driven transport across the skin

		for glucose sampling

July 25	Thursday Morning

ELECTRICALLY DRIVEN TRANSPORT ACROSS BIOLOGICAL BARRIERS II.


Harry Bodde (Discussion Leader)

09:00 - 10:00	EBERHARD NEUMANN  Lipid rearrangements in the

		electroporation-resealing cycle and biotechnological applications

10:00 -10:30	Coffee break

10:30 - 11:30	LESLIE TUNG  Electroporation of cardiac cell membranes with

		defibrillation-level electric fields

11:30 - 12:30	UWE PLIQUETT  Quantitative characterization of ion and molecule

		transport across skin using fluorescence and electrochemical methods

12:30	Lunch

17:00 - 18:00	Social/Poster IV

18:00	Dinner


	Thursday Evening

ELECTRICALLY DRIVEN TRANSPORT ACROSS BIOLOGICAL BARRIERS III.

Veronique Preat (Discussion Leader)



18:00 - 18:15	Business meeting; conference evaluation forms

18:30 - 19:30	YURI CHIZMADZHEV  Physical mechanism of ion and molecule

		transport across skin from "low" to "high" voltages

19:30	Conference dinner


July 26	Friday Morning

ELECTRICALLY DRIVEN TRANSPORT ACROSS BIOLOGICAL BARRIERS IV.

Betty Sisken (Discussion Leader)

09:00 - 10:00	LLUIS M. MIR  Electropermeabilization of living tissue for

		medical therapy based on local drug delivery to tumors

10:00	Coffee available, but no formal break

10:00 - 11:00	CLAUDE NICOLAU  Electroporation and electroinsertion for medical

		therapy based on cell manipulation

11:00 - 12:00	RAPHAEL LEE  Reversible and irreversible cell membrane

		electroporation in electrical injury

12:00	Lunch

13:00	Bus departs for Boston airport


From owner-emf-bio@net.bio.net Sun Jan 21 22:00:00 1996
Path: biosci!biosci!not-for-mail
From: jd_saffer@ccmail.pnl.gov
Newsgroups: bionet.emf-bio
Subject: BEMS WWW Home Page
Date: 22 Jan 1996 05:29:11 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
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The Bioelectromagnetics Society now has a WWW home page.
The URL is 

http://w3.pnl.gov:2080/health/bems/

I welcome comments or suggestions regarding this page. 

Jeff Saffer
Pacific Northwest National Laboratory
jd_saffer@pnl.gov



From owner-emf-bio@net.bio.net Sun Jan 21 22:00:00 1996
Path: biosci!biosci!not-for-mail
From: afrey@uunet.uu.net (Allan Frey)
Newsgroups: bionet.emf-bio
Subject: brain cancer meta-analysis
Date: 22 Jan 1996 13:55:02 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
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I understand that Leeka Kheifets...
of EPRI conducted a Meta-analysis of a number of brain cancer epi studies.
Has anyone read the report and have any thoughts on it?  

I understand that Kheifets' interprets the data in a toxicology context. A
toxicology context assumption is contrary to theory and data from wet 
experiments.  Thus, if the author in fact used this assumption, the 
conclusions would be rather questionable.  

Allan
 
Allan H. Frey				email afrey@uunet.uu.net
11049 Seven Hill Lane			voice 301.299.5181 
Potomac, MD 20854, USA




From owner-emf-bio@net.bio.net Mon Jan 22 22:00:00 1996
Path: biosci!biosci!not-for-mail
From: afrey@uunet.uu.net (Allan Frey)
Newsgroups: bionet.emf-bio
Subject: emf-bio charter reposting
Date: 22 Jan 1996 19:07:41 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
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The emf-bio Newsgroup was set up by the International Society for
Bioelectricity, a FASEB* Society (afrey@uunet.uu.net  Allan H. Frey),
for use by the biological research community.

*FASEB (The Federation of American Societies in Experimental Biology) is
the largest coalition of life sciences societies in the United States, and 
represents over 42,000 biomedical and biological scientists.

Charter and moderation policy:

The purpose of the Newsgroup is to provide a means of easy
communication among people doing research in or interested
in electromagnetic field interactions with biological systems.
It also provides the general biological community with a
window into a field which has broad implications for biology.

The Newsgroup is primarily for discussions among bioscientists.
Lay people interested in hazards should contact the appropriate
groups for such information such as the National EMR
Alliance (212-554-4073).  Those interested in arguing about
hazards, which is a policy issue, have other forums where
discussions of hazard policy issues are appropriate.

The Newsgroup can be used for activities such as discussion of books, 
articles, methods and experiments. Theories can be debated and the 
validity of experiments and approaches can be discussed.  Important new 
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accepted for publication.  Announcements of funding for new programs and
jobs can be posted. 

The newsgroup is moderated, but the bounds of the charter are loose. Only 
the clearly inappropriate messages as defined by the charter will not 
appear. 


The emf-bio newsgroup is a regular usenet group.
You can access it when you read newsgroups. The first time type:

   get bionet.emf-bio

After that it will appear as a newgroup (if there is news) whenever you read
the newsgroups that you have subscribed to.

If you only have email and can't  read newsgroups, do the following:
send a mail message to the Internet address

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Leave the Subject: line of the message blank and enter the following
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This message will be automatically read by the computer and your
e-mail address will be extracted from the mail header and added to the
list.

Allan
 
Allan H. Frey, Moderator		email afrey@uunet.uu.net
11049 Seven Hill Lane			voice 301.299.5181 
Potomac, MD 20854, USA

How to look at archives:
------------------------------------

Archives for EMF-BIO/bionet.emf-bio are kept in the
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From owner-emf-bio@net.bio.net Wed Jan 24 22:00:00 1996
Path: biosci!biosci!not-for-mail
From: mh@ind.rwth-aachen.de (Michael Huebler)
Newsgroups: bionet.emf-bio
Subject: Looking for: NCRP-study (draft?)
Date: 25 Jan 1996 07:46:35 -0800
Organization: RWTH -Aachen / Rechnerbetrieb Informatik
Lines: 17
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Hi,

I am looking for this NCRP-study on biological effects of EMF etc.

An internal draft of this study has probably been published by "New
Scientist", but I'm not sure, an I don't have access to this magazine.

Could anyone post this to me?

Thanks,

Michael

mh@ind.rwth-aachen.de




From owner-emf-bio@net.bio.net Sat Jan 27 22:00:00 1996
Path: biosci!biosci!not-for-mail
From: ccardin@CAM.ORG (Cardinal,Claude)
Newsgroups: bionet.emf-bio
Subject: Re: brain cancer meta-analysis
Date: 28 Jan 1996 15:01:58 -0800
Organization: Communications Accessible Montreal
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In article <QQzzqz06996.199601222128@rodan.UU.NET>, afrey@uunet.uu.net
(Allan Frey) wrote:

> I understand that Leeka Kheifets...
> of EPRI conducted a Meta-analysis of a number of brain cancer epi studies.
> Has anyone read the report and have any thoughts on it?  
> 
> I understand that Kheifets' interprets the data in a toxicology context. A
> toxicology context assumption is contrary to theory and data from wet 
> experiments.  Thus, if the author in fact used this assumption, the 
> conclusions would be rather questionable.  
> 
> Allan
>  
> Allan H. Frey                           email afrey@uunet.uu.net
> 11049 Seven Hill Lane                   voice 301.299.5181 
> Potomac, MD 20854, USA

Allan, I would greatly apprciate if you could be more explicit on what is
a Toxicology context assumption.  Thanks for your collaboration



From owner-emf-bio@net.bio.net Sun Jan 28 22:00:00 1996
Path: biosci!biosci!not-for-mail
From: afrey@uunet.uu.net (Allan Frey)
Newsgroups: bionet.emf-bio
Subject: reply re tox assumption
Date: 29 Jan 1996 08:03:10 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
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Claude Cardinal, in response to my Kheifets study posting asks:
 
>Allan, I would greatly apprciate if you could be more explicit on what is
>a Toxicology context assumption.

Below is the answer, a segment from my book "On the nature of 
electromagnetic field interactions with biological systems"
Allan
 
Allan H. Frey				email afrey@uunet.uu.net
11049 Seven Hill Lane			voice 301.299.5181 
Potomac, MD 20854, USA

As a result of this area of research having its real start because of a 
concern about hazards in the 1940's, the tendency has been for people to 
use a toxicology model as their frame of reference in the selection, design
and analyses of experiments.  They have tended to set up experiments to 
look for a "dose-response relationship" between electromagnetic field 
exposure and a biological variable.  But is a toxicology model appropriate 
as a guide for biological research with electromagnetic fields?  It's a 
crucial question for, as Burke (1) and others have made quite clear our 
frame of reference determines what we look at and how we look.  And as a
consequence, this determines what we find . 
 
Theory and data show that this is the wrong model (2,3,4).  
Electromagnetic fields are not a foreign substance to living beings like 
lead or cyanide.  With foreign substances, the greater the dose, the greater
the effect Q a dose-response relationship.  Rather, living beings are 
electrochemical systems that use very low frequency electromagnetic 
fields in everything from protein folding through cellular communication 
to nervous system function.  To model how em fields affect living beings, 
one might compare them to the radio we use to listen to music.
The em signal the radio picks up and transduces into the sound of music is
almost unmeasureably weak.  At the same time there are, in toto, strong 
em fields impinging on the radio.  We don't notice the stronger em signals 
because they are not the appropriate frequency or modulation.  Thus, they 
don't disturb the music we hear.  However, if you impose on the radio an 
appropriately tuned em field or harmonic, even if it is very weak, it will 
interfere with the music.  Similarly, if we impose a very weak em signal 
on a living being, it has the possibility of interfering with normal function
if it is properly tuned.  This is the model that much biological data and 
theory tell us to use, not a toxicology model.

1.  Burke J. The day the Universe Changed. Boston: Little and Co,  1985.

2.  Frey A H.   Electromagnetic field interactions with biological systems. 
FASEB Journal 1993; 7:272-281

3.  Frey A H.  Evolution and results of biological research with low-
intensity nonionizing radiation.  In:  A. A. Marino, ed. Modern Bioelectricity
New York: Marcel Dekker, Inc  1988: 785-837.

4.  Frey A H.  Biological function as influenced by low power modulated RF 
energy.  IEEE Trans on Microwave Theory and Techniques 1971;  MTT-
19:153-164




From owner-emf-bio@net.bio.net Mon Jan 29 22:00:00 1996
Path: biosci!biosci!not-for-mail
From: sastre@access.digex.net
Newsgroups: bionet.emf-bio
Subject: Re: reply re tox assumption
Date: 30 Jan 1996 08:07:08 -0800
Organization: Express Access Online Communications, USA
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NNTP-Posting-Host: net.bio.net

>In a previous posting, Allan Frey questioned the recent

>brain cancer meta-analysis by Kheifets et al.  Claude Cardinal offered a reply, and Frey wanted

>clarification about the " toxicology context" of the meta-analysis.


As a researcher in bioelectromagnetics who has also worked as a professional pharmacologist, maybe I can 
add some perspective to this question.
Pharmacological and toxicological experiments explore, among other things, what the dose-response 
relationship may be between an exposure and a biological response.  In searching for such a 
dose-response, the experiments are equally informative whether they find a dose-response or not find such 
a relationship.  Similarly, they are informative if they do find one that is monotonically increasing or if they find 
a relationship that has some other shape.  There are many examples of drug dose-response curves 
(generally called biphasic) that look like an inverted "U", what someone in bioelectromagnetics may call a 
"window."  No toxicologist worth his or her salt would design an experiment that would be informative only if 
there existed a monotonic dose-response relationship.  Simiarly, a bioelectromagnetics experiment or study 
conducted in such a fashion would not very very informative either.
In bioelectromagnetics we have a number of theoretical mechanisms as candidates for reported magnetic 
field-biological interactions.  ALL of the candidate mechanisms predict (to a varying level of detail) how the 
biological response may vary as a function of magnetic field intensity or frequency, whether they are 
resonance mechanisms (e.g., Liboff; Blanchard-Blackman, Lednev), free-radicals (e.g. Walleczec), 
intermittency (e.g. Litovitz) or others.  None of the mechanisms have been proven for any reported effect, 
and all need, before they can be accepted or rejected, to match their predictions (including dose-response) 
to the experimental data that may be collected.  Thus, doing experiments or other studies that explore 
dose-response in bioelectromagnetics is indispensable both theoretically as well as experimentally.
If only from these considerations, Kheifetz and her colleagues are on very solid ground in their analysis; 
while their approach may not be the only possible approach, it is certainly one backed by considerable 
background, both within and outside the general area of bioelectromagnetics.

Antonio Sastre, Ph.D.
A.S. Consulting & Research
and
Adjunct Associate Professor, Pharmacology, Cornell Medical College




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