From owner-7tms_r@net.bio.net Tue Apr 06 23:00:00 1999 Path: biosci!biosci!not-for-mail From: edvard@fagmed.uit.no (Oyvind Edvardsen) Newsgroups: bionet.molbio.proteins.7tms_r Subject: Mutant database tinyGRAP release 7 is available Date: 7 Apr 1999 08:24:13 -0700 Organization: Univ. of Tromso, IMB Lines: 86 Sender: daemon@net.bio.net Approved: lfk@gcrdb.uthscsa.edu Distribution: world Message-ID: <7eftat$ppg@net.bio.net> Reply-To: edvard@fagmed.uit.no NNTP-Posting-Host: net.bio.net We are pleased to announce the availability of release 7 of tinyGRAP. tinyGRAP release 7 is a collaborative release between * Leiden Amsterdam Center for Drug Research/LACDR (M. Beukers) * Royal Danish School of Pharmacy/DFH (K. Kristiansen) * University of Tromso (O. Edvardsen) * BIOcomputing group at EMBL, Heidelberg (G. Vriend et al.). Changes: * Added ~2600 mutants. * Insertion mutants have been added. * Receptor peptides have been added. * Annotation on experimental conditions and qualitative effects of mutagenesis is available for ~50% of the mutants (i.e. all mutants added in this release and the previous release). * Around 280 duplicates were merged. * According to information in Swiss-Prot 37 the following information has been checked & updated: -all secondary structure assignments -species information -amino acids and their positions (numbers) -links into OMIM * Receptor names have been updated. * Annotation on receptor splice variants has been added. * All bibliographic information has been checked and updated. * Database indices have been made more reliable to ensure correct answers. * All software has been rewritten. Simpler methods for linking into tinyG= RAP have been developed. * A dedicated tinyGRAP server has been installed. o Margot Beukers at LACDR and Kurt Kristiansen at DFH have done the tedious job of entering data. Margot has also been active in the development of all parts of the database system.=20 o Gert Vriend et al. at BIOcomputing, EMBL, Heidelberg has contributed = by arranging yet another fruitful GPCR workshop (Heidelberg, March this year), by his interest in GPCRs and by taking part in and creating interesting discussions. o Oyvind Edvardsen at University of Tromso has created programs to check input data and has done all the other software and database maintainance stuff. We would like to thank all the participants at the GPCRDB workshop in Heidelberg, March this year, for all comments and suggestions. In order to continue to provide computerized mutant data we need YOUR help. If you can't locate YOUR paper(s) in tinyGRAP, at least send us a notification. Even better if YOU would send reprint(s). The=20 postal address is given below. User feedback is always welcome. Access tinyGRAP from the GRAP homepage: http://www-grap.fagmed.uit.no/GRAP/homepage.html Above is the one and only URL that can be guaranteed to be persistent. Alternatively, you can access tinyGRAP directly on the dedicated server http://tinyGRAP.uit.no/. Other access method: Mutant data can be accessed from the services of the GPCRDB at http://www.gpcr.org/7tm/. On behalf of the tinyGRAP release 7 team, =D8yvind Edvardsen - --=20 - -o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-o-= o-o- ___ _ =20 | /| _| |_ _| __ _ _| _ _ |/_| \/ \/ | |\| |_| |_ |_| \/ |_|_ | |_| _\ |_' |\| / _________________________________________________________________________= ____ Dept. of Pharmacology | TelePhone: +47 77 64 66 33 Institute of Pharmacy | TeleFax: +47 77 64 66 45 University of Troms=F8 | Email: edvard@fagmed.uit.no N-9037 TROMS=D8, NORWAY | URL: http://capsg.farmasi.uit.no/ - -------------------------------------------------------------------------= - ----- From owner-7tms_r@net.bio.net Tue Apr 06 23:00:00 1999 Path: biosci!biosci!not-for-mail From: "QSAR2000" Newsgroups: bionet.molbio.proteins.7tms_r Subject: QSAR2000 congress Date: 7 Apr 1999 08:23:48 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 72 Sender: daemon@net.bio.net Approved: lfk@gcrdb.uthscsa.edu Distribution: world Message-ID: <7efta4$pn7@net.bio.net> NNTP-Posting-Host: net.bio.net - --PART-BOUNDARY=.19904062003.ZM11134.pharm.uni-duesseldorf.de Content-Description: Text Content-Type: text/plain ; charset=iso-8859-1 Content-Transfer-Encoding: quoted-printable X-Zm-Decoding-Hint: mimencode -q -u #########################################################################= ###### 13th European Symposium on Quantitative Structure-Activity Relationshi= ps 27 August - 1 September 2000 Rational Approaches to Drug Design #########################################################################= ###### First Announcement and Invitation The Institute for Pharmaceutical Chemistry at the Heinrich-Heine-Universi= ty Duesseldorf is proud to announce the 13th European Symposium on Quantitat= ive Structure-Activity Relationships to be held in Duesseldorf, 27 August - 1= September 2000. The congress will be organized by the local organizing committee under the patronage of the Ministry for Education and Science o= f the state of Nordrhein-Westfalen. The city of Duesseldorf is located in the North-West of Germany, at short= distance from K=F6ln, Bonn and the Ruhrgebiet. The scientific programme will include an opening lecture by Camille G. We= rmuth on "The Impact of QSAR and CAMD Methods on Drug Discovery", eight plenary= lectures by well known scientists on the most actual topics in todays dru= g design research, as well as 24 selected communications and a poster sessi= on. For further information please address the conference home page http://pharm.uni-duesseldorf.de/qsar2000 Those interested in attending the Symposium and presenting a poster or an= oral communication are invited to return the Preliminary Registration Form (lo= cated on the conference home page). Provisional application does not imply any obligation, but will greatly assist the organizing committee in its prepa= ratory work and ensure receipt of the second annoucement which will be distribut= ed end of 1999. Hoping to meet you 2000 in Duesseldorf H.-D. Hoeltje Institute for Pharmaceutical Chemistry Heinrich-Heine-University Duesseldorf Universitaetsstr. 1 D-40225 Duesseldorf, Germany Tel: +49 211 811 3835 - Fax +49 211 811 3847 e-mail: qsar2000@pharm.uni-duesseldorf.de - --PART-BOUNDARY=.19904062003.ZM11134.pharm.uni-duesseldorf.de-- From owner-7tms_r@net.bio.net Tue Apr 06 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Judah Boulet Newsgroups: bionet.molbio.proteins.7tms_r Subject: bacteriorhodopsin Date: 7 Apr 1999 08:22:18 -0700 Organization: Emory University Lines: 5 Sender: daemon@net.bio.net Approved: lfk@gcrdb.uthscsa.edu Distribution: world Message-ID: <7eft7a$pij@net.bio.net> Reply-To: jboulet@cellbio.emory.edu NNTP-Posting-Host: net.bio.net I am trying to get some feedback on a ongoing debate. The question revolves around the use of bacteriorhodopsin as a relevant model for all G-protein linked receptors. I believe it is a good model to use to get better understanding of structure/function relationships. ANy feedback would be great! From owner-7tms_r@net.bio.net Mon Apr 19 23:00:00 1999 Path: biosci!biosci!not-for-mail From: RNeubig@umich.edu (Rick Neubig) Newsgroups: bionet.molbio.proteins.7tms_r Subject: Mol Pharm BBS Journal Club Date: 20 Apr 1999 08:05:57 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 15 Sender: daemon@net.bio.net Approved: lfk@gcrdb.uthscsa.edu Distribution: world Message-ID: <7fi54l$ij9@net.bio.net> NNTP-Posting-Host: net.bio.net Hello 7tms'rs, Check out the Journal Club by Bryan Roth on the ASPET Division for Molecular Pharmacology Bulletin Board at http://swift.med.umich.edu/~MolPharm RNA EDITING OF THE HUMAN 5-HT2C RECEPTOR SILENCES CONSTITUTIVE ACTIVITY Niswender, Copeland, Herrick-Davis, Emeson and Sanders-Bush JBC 274: 9472-9478-1999 Rick P.S. If you want to get the Journal Club postings by e-mail log on to the BBS through the web address above then click More/Mailing Lists and click the checkbox for Journal Club and any other mail lists to which you'd like to subscribe. From owner-7tms_r@net.bio.net Mon Apr 19 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Joan Boyce Newsgroups: bionet.molbio.proteins.7tms_r Subject: 1999 Source Book Available Free to Researchers Date: 20 Apr 1999 14:00:34 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 17 Sender: daemon@net.bio.net Approved: lfk@gcrdb.uthscsa.edu Distribution: world Message-ID: <7fipti$ai7@net.bio.net> Reply-To: boyce@cshl.org NNTP-Posting-Host: net.bio.net Obtain a free copy of the 1999 Source Book, a comprehensive guide to bioresearch products, by filling in the request form at the BioSupplyNet site: http://www.biosupplynet.com. The Source Book provides up-to-date information about reagents, lab instrumentation, antibodies, custom services and supplies. Biomedical researchers will find that the unique organization of the Source Book simplifies product searching and speeds the gathering of comparative information. The Source Book indexes products in 2650 categories, and provides up-to-date contact information, including WWW and e-mail addresses, for 3500 suppliers. Bench Basics comparative tables allow apples-to-apples comparisons of products. A special Lab Set-up Check List simplifies the process of putting together a new laboratory. Order your free copy at The BioSupplyNet web site at http://www.biosupplynet.com From owner-7tms_r@net.bio.net Mon Apr 19 23:00:00 1999 Path: biosci!biosci!not-for-mail From: roth@biocserver.BIOC.CWRU.Edu Newsgroups: bionet.molbio.proteins.7tms_r Subject: position available Date: 20 Apr 1999 08:04:16 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 27 Sender: daemon@net.bio.net Approved: lfk@gcrdb.uthscsa.edu Distribution: world Message-ID: <7fi51g$i5s@net.bio.net> NNTP-Posting-Host: net.bio.net A position is available immediately for an individual interested in high through-put screening of GPCR's and transporters. The individual will perform binding and functional assays for a variety of GPCR's, transporters and channels as part of the NIMH Psychoactive Drug Screening Program (see URL below). Experience with radioligand binding and functional assays required. For information, contact me via email and/or phone. Bryan Roth MD, PhD Departments of Psychiatry, Biochemistry and Neurosciences Room W438, Department of Biochemistry 10900 Euclid Avenue Cleveland, OH 44106-4936 216-368-2730 (Office) 216-368-3419 (Fax) roth@biocserver.cwru.edu For information about the NIMH Drug Screening Program view web site at: http://meds20785.cwru.edu/myweb/newpage13.htm Roth lab home page at: http://meds20785.cwru.edu/rothlab/ From owner-7tms_r@net.bio.net Mon Apr 19 23:00:00 1999 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.molbio.proteins.7tms_r Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 20 Apr 1999 08:05:04 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 232 Sender: daemon@net.bio.net Approved: lfk@gcrdb.uthscsa.edu Distribution: world Message-ID: <7fi530$iga@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! - ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. - -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. - ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? - --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? - ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. - ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI - ------------------------------------------------------------------ node at computer net.bio.net: - ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at - -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): - ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. - ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms.