class switching

Ralph A. Sorensen Ralph.A.Sorensen at CC.GETTYSBURG.EDU
Wed Jul 21 10:59:27 EST 1993

Recent reports on the CD40L gene responsible for x-linked hyper IgM syndrome 
(HIM) pull together a lot of data about the cytokine control of class 
switching. Two patterns emerge. IL-2, IL-10, and TGF-beta control IgG1-3 and 
IgA secretion. IL-4 controls IgG4 and IgE secretion. My question concerns 
IgA. Given the order of constant chain genes in the human, is the IgA in the 
former case IgA1? Was IgA2 looked for in the latter case? Just wondering.

                                                            Ralph A. Sorensen
                                                            Biology Department
                                                            Gettysburg College
                                                            rsorense at
                                                            (717) 337-9171
                                                            (717) 337-6666 (fax)

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