Indomethacin toxicity in rats

Dr. Subburaj Ilangumaran ilanguma at
Fri Sep 15 14:54:34 EST 1995

Dear colleagues,

Indomethacin adnimistered to Lewis, BN, and F1(Lewis x BN) rats resulted in 
mortality in 4-5 days. Indomethacin was prepared freshly in sodium carbonate 
buffer and administered i.p. or by gavage, 0.5 or 1 mg per rat. The 
recommended dose in the literature is 1 mg/rat/day. I haven't come across any 
report on toxicity at this dosage. It woul be of immense help if someone could 
share his/her experience and suggest alternate means to inhibit the 
cyclooxygenase pathway in rats.


Yours sincerely,

Subburaj Ilangumaran, Ph. D.
E-mail: ilanguma at

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