What is the prime (') in F(ab)'2
Peritt_d at a1.mscf.upenn.edu
Wed Sep 20 14:34:54 EST 1995
In article <17ADE145EF at aarlo.moffitt.usf.edu> Steven Shivers,
SHIVERS at AARLO.MOFFITT.USF.EDU writes:
>The above answer is almost right, but it doesn't go far enough. The
>enzyme papain cleaves the Ig molecule above the interchain (H-H)
>disulfide bonds, such that 2 Fab fragments are produced. The enzyme
>pepsin cleaves the Ig molecule below the disulfide bonds so that the
>2 fragments remain attached. Since the latter fragments are slightly
>larger than the former ones, the fragments are represented as
>F(ab)'2. Further cleavage of the disulfide bonds creates 2 Fab'
>fragments, which are again slightly larger than the Fab fragments
>produced by papain cleavage.
I find your description of Fab generation fascinating and your details
What is the (') that you put after Fab' or F(ab)'2. The little mark that
sits above the letter b is called prime. Why is it there. I am
begginning to think it is a vestibular mark like the appendix but the
history of this mark is what I seek....
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