MHC restriction

Ken Miyasaki kmiyasak at
Thu Feb 27 17:01:06 EST 1997

I was just curious as to how immunologists viewed "MHC restriction."
Does it really exist? Isn't it just a laboratory artifact (based upon
measurement of secondary immune responses)? Doesn't the TCR see mainly
the antigen and not the MHC (with greater than three orders of magnitude
difference in affinity). So why was the 1996 Nobel Prize awarded to
people who proposed this dual cognition stuff?

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