DNA-RNA hybrid cross-linking

[León Fernando García-Martínez]

Hello:
I have a DNA-RNA hybrid that comes apart in my reaction conditions (75 mM NaCl).
The hybrid is stable at 0.5X SSC.  I was thinking about trying to
cross-link both chains, but most information I have come across with is
regarding Protein-nucleic acid cross linking.  Any Ideas?

Leon F. Garcia Martinez
U.T. Southwestern Medical Center