sense versus anti-sense terminology

Daniel B. Oerther oerther at coewl.cen.uiuc.edu
Wed Jun 12 14:47:41 EST 1996

Dear Netters,

I have a problem with the definition of sense and anit-sene RNA (DNA).

If a single-stranded RNA transcript has the sequence:


Then, the double-stranded DNA sequence from whence it came is:


So, which is the sense strand, and which is the anti-sense strand???

My understanding is that the DNA strand which has the SAME sequence as the
RNA transcript (with the substitutions of T for U) is called the sense
strand, while the DNA strand with the COMPLEMENT sequence is known as

PLEASE NOTE: I am looking for DEFINITIVE evidence (could you site a
reference, either a text book or favorite publication), not merely an
expert opinion.

Thanks in advace,


Daniel B. Oerther
Environmental Engineering

University of Illinois at Urbana-Champaign
205 N. Mathews Ave.
Urbana, IL 61801

U of I mail code: 250

voice: 217/ 333-6978
fax: 217/ 333-9464
web: http://www.cen.uiuc.edu/~oerther

More information about the Microbio mailing list

Send comments to us at biosci-help [At] net.bio.net