Would bacteriophages kill resistant bacteria?

Oladele A. OGUNSEITAN oaogunse at UCI.EDU
Sat Mar 23 18:52:35 EST 1996

Actually, the cystic fibrosis story is very FUNNY ! - In fact one of the 
phages (D3, I beleive) causes a lysogenic conversion for Pseudomonas 
aeruginosa, the species that complicates matters for cystic fibrosis 
patients. The lysogenic conversion results in increased alginate 
production leading to more mucus etc.  Here is a case where untested 
phage therapy could lead to further complications of disease.  I wonder 
if that really happened to cystic fibrosis patients who inhaled viral 

Dele Ogunseitan

Department of Environmental Analysis and Design
University of California

On 22 Mar 1996, Nicholas Landau wrote:

> klasteos at student.dtu.dk ("Steen OEstergaard ", c917243) writes:
> >Dear reader,
> >Behind the retorical question in my 'Subject' is the idea of using virulent
> >bacteriophages for killing antibiotic resistant bacteria. A well chosen virus
> >should be able to pass through a mammal digestion system and infect the
> >resistant bacterium when it gets in contact with it.
> >I would like comments to this idea, if you have any.
> I do not have a citation for you, just something a colleague told
> me during a chat.  His specialty is bacterial adhesion, and we were
> discussing the problems of cystic fibrosis patients in that their
> lungs become mired with exopolysaccharides of bacterial origin.
> He mentioned that, before effective surfactant and antibiotic
> treatments had been developed, patients were given viral suspensions
> in aerosol by inhalation.  The bacteriophage would control the
> density of the bacterial populations for a short time.
> Sorry, but that's all I know about that one.  As far as I can see,
> there is no reason why this method of therapy would not work.
> Nicholas Landau
> Dept. of Biochemistry and Microbiology
> Rutgers University

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