Actually, the cystic fibrosis story is very FUNNY ! - In fact one of the
phages (D3, I beleive) causes a lysogenic conversion for Pseudomonas
aeruginosa, the species that complicates matters for cystic fibrosis
patients. The lysogenic conversion results in increased alginate
production leading to more mucus etc. Here is a case where untested
phage therapy could lead to further complications of disease. I wonder
if that really happened to cystic fibrosis patients who inhaled viral
Department of Environmental Analysis and Design
University of California
On 22 Mar 1996, Nicholas Landau wrote:
>klasteos at student.dtu.dk ("Steen OEstergaard ", c917243) writes:
>> >Dear reader,
>> >Behind the retorical question in my 'Subject' is the idea of using virulent
> >bacteriophages for killing antibiotic resistant bacteria. A well chosen virus
> >should be able to pass through a mammal digestion system and infect the
> >resistant bacterium when it gets in contact with it.
>> >I would like comments to this idea, if you have any.
>> I do not have a citation for you, just something a colleague told
> me during a chat. His specialty is bacterial adhesion, and we were
> discussing the problems of cystic fibrosis patients in that their
> lungs become mired with exopolysaccharides of bacterial origin.
>> He mentioned that, before effective surfactant and antibiotic
> treatments had been developed, patients were given viral suspensions
> in aerosol by inhalation. The bacteriophage would control the
> density of the bacterial populations for a short time.
>> Sorry, but that's all I know about that one. As far as I can see,
> there is no reason why this method of therapy would not work.
>> Nicholas Landau
> Dept. of Biochemistry and Microbiology
> Rutgers University