Bacteriophage replacement of antibiotics

John Cherwonogrodzky jcherwon at dres.dnd.ca
Fri Mar 29 15:57:27 EST 1996

Dear Colleagues:
      There is a discussion on the net about the use of bacteriophages to 
replace antibiotics in the treatment of infectious agents. This worries me 
because there is enough evidence that bacteriophages play a role in increased 
virulence (e.g. diphtheria, flesh-eating streptococci). In our own study we 
tried to use WB1 bacteriophage to clear Brucella abortus out of balb/c mice.  
The result was a 200-fold increase in spleen counts over controls (see Arch. 
Med. Vet. 27:23-28). Are you sure you want to be opening Pandora's Box?...John

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