I am taking an allied health pharmacology course, and we were discussing the
effects of beta 2 receptor stimulation and the reaction cascade that follows.
Being the type of person I am, I asked the question; How is adenylate cyclase
released as a result of beta 2 stimulation??? My instructor said he didn't
know :(.
I have done some searching and would like to verify (or get straightend out
about) my interpretation of what I have found. Also, I have some other
(basic?) questions.
As near as I can tell stimulation to the beta 2 receptor acts as a "1st
messenger" that causes a "conformational" change on the inside of the
phospholipid bilayer of the cell that in turn releases adenylate cyclase(?),
which then after release to the inside of the cell acts as a "second
messenger" to carry out the function of the original stimulus.??
Also, are beta 2 receptors integral protiens or peripheral??? What role does
Mg+ play in this senario and where does Mg+ come into play???
Thanx in advance,
E.C.
