Andre Burnens BURNENS at VBI.unibe.ch
Thu Nov 21 16:44:30 EST 1996

stutjamalgeo at SPOCK.COLSF.EDU wrote:
> From:   stutjamalgeo 15-NOV-1996 16:56:11.91
> To:     microbio at net.bio.net
> CC:
>    For whoever can answer me:
>    What Salmonella strains are out there that are non-pathogenic to humans,
> but can be used for experimentation on mice?  I'm trying to study the
> effects of bacteriophage 01 and P22 against Salmonella, and my school does
> not have the facilities needed to prevent any possible outbreak of pathogenic
> Salmonella from mice.
>    Any comments will be greately appreciated.
> George Tjamaloukas
> Colle
> College of St.Francis
> stutjamalgeo at vax.colsf.edu
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Would need more specific info on type of experiments planned. 
Pathogenicity of salmonellae for mice does not parallel human 
pathogenicity. Probably all salmonellae are more or less pathogenic for 
humans. Most strains would cause gastroenteritis, and sometimes more 
serious disease in humans, but only a few will produce illness in mice 
(usually fatal systemic infections). Those isolates would invariably be 
pathogenic for humans. I doubt that the available 'nonpathogenic' vaccine 
strains of Salmonella will produce any significant disease in mice.
Andre P. Burnens MD
National Reference Laboratory for Foodborne Diseases
Institute for Veterinary Bacteriology, University of Berne
Laenggass-Strasse 122, CH-3012 Berne, Switzerland

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