Bacteriophage P1

D. Duggan dduggan at micro.ifas.ufl.edu
Thu Oct 3 11:16:45 EST 1996

On 24 Sep 1996 16:53:22 GMT, 
Gunilla B Krook  <gkrook at cc.Helsinki.FI> wrote:

>Wai (Denny) Lee (leew at rohan.sdsu.edu) wrote:
>: I am trying understand a microbiology paper with very little biology
>: background.  Can anyone explain the following terms to me?
>: Bacteriophage P1, P1 lytic growth and lysogenic P1.  Thanks.
>BActeriophage P1 is just the name. You need to understand the life cycle
>of the phages which have lysogenic and lytic cycles. P1 infect the
>host(E.coli), and replicate its DNA and produce the proteins for its
>morphogenesis immediately, and release the progenies, this is the lytic
>cycle. if P1 does not propagate its slef after infection, instead
>integrate into chromosome, and become part of chromosome DNA, and keep
>rfeplication with chromosome together, this is the lysogenic cycle, it
>is possible the lysogenic DNA enter lytic cycle by some induction, such
>as, if there is temperature senstive mutation, increasing Tm will lead
>to release the phage.  Hope this helps!  more information:
>cheng.luo at plantphys.umu.se
>This isn't quite accurate - for one thing P1 lysongenizes as a plasmid,
unlike phage Lambda, it does not fuse with the chromosome. A lysogenic cell 
is induced by conditions that induce SOS response, conditions like 
radiation damage or certain chemicals, or loss of repression such as 
described above in strains carrying a temperature sensitive repressor gene.

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