Nalidixic acid

Mike O'Hara mjohara at pacbell.net
Thu Oct 9 21:12:51 EST 1997

B. REWALT wrote:
> Nalidixic acid inhibits DNA gyrase.  Why will this inhibit DNA
> replication?
>  Rifampicin inhibits RNA polymerase.  Why will this stop protein
> synthesis?  Will nalisixic acid inhibit protein synthesis?
> THanks for any help you can offer!
> bengi @ nmsu.edu

The rifampicin means no or reduced mRNA hence no protein. 
The general suggestion is that DNA gyrase is required for replication
(introducing supercoils to return to correct packing form perhaps) so no
gyrase, poor replication.


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