Domains & Motifs?

pjf zinc at genetics.utah.edu
Tue Oct 28 12:59:41 EST 1997

AFAIK, domains are based upon either a known protein structure or
protease mapping. that is, it is a region of a protein separate from
other regions and that can sometimes fold and be active independent of
the whole protein. for instance, transcriptional activation domains
are usually separate from DNA binding domains by proteolysis and, when 
attached to a different protein will confer the transcriptional
activation to them.

a motif is simply a sequence string that has been found in multiple
(not necessarily related) proteins and that generally indicates a
similar biochemical activity. examples of this are the zinc finger
motif (around 21 aa) and the dsRNA binding motif (dsRBM, can't
remember how long).



dicklai at usa.net (Dick Lai) writes:

> HI all,
> 	What's the different between "Domains" and "Motifs"? Thanks!
> Best Regards,
> Dick Lai
> ===========================
> E-mail:dicklai at usa.net
> ===========================

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