Domains & Motifs?

Lloyd Graham lloyd.graham at molsci.csiro.au
Thu Oct 30 01:53:53 EST 1997

In article <34566887.992007 at news.hku.hk>, dicklai at usa.net (Dick Lai) wrote:

> HI all,
>         What's the different between "Domains" and "Motifs"? Thanks!
> Best Regards,
> Dick Lai
> ===========================
> E-mail:dicklai at usa.net
> ===========================

In addition to features mentioned in the previous replies, a key
distinction is size. A domain is a portion of polypeptide chain, usually
100-300 amino acid residues in length, which is considered to have the
characteristics of a complete globular protein. A motif is a short
sequence found in otherwise different proteins, which can be as little as
3 residues long (e.g. the RGD cell adhesion motif). The PROSITE database
contains an extensive collection of known motifs and their functions.



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