antibodies against peptides

Tobias Dassler t.dassler at lrz.uni-muenchen.de
Fri May 8 13:20:49 EST 1998

I'm working with a membrane protein of E.coli which is quite hydrophobic 
and which I can't overproduce in sufficient amounts for purification and 
antibody production. So I'm trying to find special peptide-sequences of 
the protein for use as antigens. 
Now my questions: 
Does anyone out there know anything about the properties such a peptide 
sequence has to have to be suitable as an antigen? Or which amino acids 
shouldn'd be present at all? Are there any algorithms for calculating the 
"antigenicity" of a peptide? Are there any servers/programs in the net to 
get informations from?
Thanks for your help! 

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