Post-doctoral positions available to study the signal transduction
pathways regulating pseudohyphal differentiation in Saccharomyces
cerevisiae, and in mating, filamentous growth, and virulence in
Cryptococcus neoformans. Our recents studies define a conserved G
protein and cAMP dependent signaling cascade that operates in parallel
with MAP kinase signaling cascades regulating differentiation in yeast
and pathogenic fungi. Current areas of interest focus on the receptors
and ligands that activate this signaling cascade, the targets of G
protein and cAMP action, components of MAP kinase signaling pathways,
and the structure and function of the MAT loci in C. neoformans. We
also study signaling pathways that are inhibited by immunosuppressive
drugs in both yeast and pathogenic fungi. Our lab is funded by the
Howard Hughes Medical Institute, grants from the National Institute of
Allergy and Infectious Disease, the National Cancer Institute, and a
Burroughs Wellcome Fund Scholar Award in Molecular Pathogenic Mycology.
Please send a description of research interests, CV, reprints/preprints,
and the
names and phone numbers of three references to:
Joseph Heitman, MD, PhD
Departments of Genetics, Pharmacology and Cancer Biology, and Medicine
Howard Hughes Medical Institute
322 CARL Building
Research Drive
Duke University Medical Center
Durham, NC 27710
919-684-2824
919-684-5458 (FAX)
heitm001 at mc.duke.edu
for recent publications, see:
EMBO Journal 16: 2576-2589, 1997
EMBO Journal 16: 7008-7018, 1997
Genes and Development, 11, 3206-3217, 1997
EMBO Journal, 17: 1236-1247, 1998
PNAS 94: 13093-13098, 1997
