On Fri, 19 Oct 2001 19:19:00 +0100, "scotratrescue"
<scotratrescue at ntlworld.com> wrote:
>Can anyone give me any info on cardiac toxicity of this drug, specifically
>for use in rats.
>searches not coming up with much.
Tilmicosin.
hexopyranosyl)-20-deoxo-20-(3,5-dimethyl-1-
piperidinyl)tylosin;
20-deoxo-20-(3,5-dimethylpiperidin-
1-yl)desmycosin;
EL-870; LY-177370;
Micotil (Elanco).
C46H80N2O13;
mol wt 869.15.
C 63.57%, H 9.28%, N 3.22%, O 23.93%.
Macrolide antibiotic; structurally related to tylosin, q.v.
Prepd as 85:15 mixture of cis/trans
isomers: M. Debono, H. A. Kirst, Eur. pat. Appl.
103,465; eidem, U.S. pat. 4,820,695 (1984, 1989
both to Lilly); M. Debono et al., J. Antibiot. 42, 1253
(1989). In vitro antibacterial activity: E. E.
Ose, ibid. 40, 190 (1987). Metabolism and tissue
residue studies in cattle: A. L. Donoho et al.,
ACS Symposium Series 503, 158-167 (1992). Trial in
treatment of calf pneumonia: E. E. Ose, L. V.
Tonkinson, Vet. Rec. 123, 367 (1988). Prophylactic
efficacy in bovine respiratory tract disease: D.
W. Morck et al., J. Am. Vet. Med. Assoc. 202, 273
(1993).
uv max: 283 nm (.epsilon. 22643). pKa' (66%
DMF): 7.4, 8.5. [.alpha.]D23 +12.75 deg (c = 0.010004
in
CHCl3, 5 cm).
THERAP CAT (VET): Antibacterial.
>>anyone?
>>Thanks
>>Donna
>>Scotrat Rescue
>
