macbeth at cs.tu-berlin.de (Andreas Pahl) writes:
>Hi,
>I cloned and sequenced a protein from a gram-positive bacteria (streptomycete) and
>much more homology to yeast, fungi and mammalians than to E.coli. So my question
>is, what may be the reason for this?
>The protein is highly conserved from human down to yeast (about 80% identity),
>but as fas as I know the split of eukaryotes and prokaryotes took earlier place
>than the split gram-positive and gram-negative bacteria.
>Bye, Andreas
>--
>###############################################################################
>Andreas Pahl email: macbeth at opal.cs.tu-berlin.de>Institut f. Biochemie u. Molekulare Biologie macbeth%opal at DB0TUI11.BITNET>TU Berlin macbeth%opal at DB0TUI11.EARN>Franklinstr. 29 Tel. +49 30 314 24168
>D-1000 Berlin 10 Fax +49 30 314 24783
>###############################################################################
You may have found a case of horizontal gene transfer from eukaryotes to
prokaryotes. Take a look at:
Doolittle, RF, DF Feng, KL Anderson, and MR Alberro
A naturally-occurring horizontal gene transfer from a eukaryote to a prokaryote
Journal of Molecular Evolution
Nov 1990 31(5):383-385
Keith Robison
Harvard University
Program in Biochemistry, Molecular, Cellular, and Developmental Biology
robison at nucleus.harvard.edu
