The following references should provide a starting point. If you are unable to
find these articles let me know and I will send you copies.
Duarte et al 1992, PNAS vol 89: 6015-6019
Rapid fitness losses in mammalian RNA virus clones due to Muller's
Steinhauer et al 1992, Gene vol 122: 281-288
Lack of evidence for proofreading mechanisms associated with an RNA
Clarke et al 1993, Journal of Virology vol 67: 222-228
Genetic bottlenecks and population passages cause profound fitness
differences in RNA viruses
Duarte et al 1993, Journal of Virology vol 67: 3620-3623
Many trillion fold amplification of single RNA virus particles fails to
overcome Muller's ratchet effect
A usefull ftp site might be ftp.bio.indiana.edu. This site certainly contains
programs for molecular biology running on vax or PC.
Any problems please e-mail me: HISCOX at IRAD.AFRC.AC.UK
Julian A Hiscox