Staining of metaphasic mammalian chromosomes reveals a banding pattern
(G/R) that reflects structural differences along the chromosome. This
pattern is known to be correlated with base composition, gene density,
replication timing, chromosome condensation, repeat sequences
(Craig & Bickmore 1993 BioEssays 15:349-354).
Uta Francke (in Cell 68:1005-1006) says also that introns from genes
located in G-bands are longer than those located in R bands... but does not
give any reference.
I am interested in the comparison of the structure of genes in the
different chromosomal compartments.
Does anyone know an article that illustrates differences in intron/exon
organization between genes from G and R bands?
Thanks for your help.
Laurent Duret
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Laboratoire de Biometrie, Genetique et Biologie des Populations
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E-mail: duret at biomserv.univ-lyon1.fr
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