Archaebacteria and the Three Kingdoms

David Faguy faguyd at methanogenone.microbio.queensu.ca
Mon Apr 18 16:07:52 EST 1994

Sorry about the previous post here it is again word wraped.

I've just finished catching up on all the posts in this discussion and, although it probably would
 have been more appropriate earlier, I have a couple of points to add regarding the monoplyetic
 nature of the Archaea and relationship to (eu)bacteria. 

	There is a system that is identical functionally and very similar structurally in the
 eubacteria and archaea - the flagellar system. However at the molecular level - there is no
 genetic similarity and in fact the molecular mechanisms are quite different.

	 All bacterial  flagellins (the protein that make up flagella) are homologous. The
 mechanism  of flagellar assembly in bacteria is quite unique and appears to be the same in all

	In the archaea flagella perform the same function and look the same but the flagellins
 are quite distinct - definetly no homology. The flagellins from the genera Halobacterium,
 Sulfolobus and most of the methanogens all of homologous N-termini. 

	Rather than being 'just another protein' that is different between Archaea and bacteria
 this is an entire system (a system described in some reviews as comprising 2% of the
 genome) which supports the distinct and monphyletic nature of the archaea (ie the
 Woese-Kandler-Wheeler paradigm). If anyone is interested (and has bothered to read this far) I
 can supply references, etc.

	I'd like to hear people's thoughts on this, especially the idea of looking at systems
 rather than gene sequences (this is not meant to be an argument for morphology vs sequence in

David Faguy
Dept. of Microbiology
Queen's University

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